ArticleAdvances in experimental medicine and biology2022
Epigenetic Mechanisms in Understanding Nanomaterial-Induced Toxicity.
Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Advancing gastric cancer treatment: nanotechnology innovations and future prospects.Cell biology and toxicology · 2024Review
- Quercetin, a Flavonoid with Great Pharmacological Capacity.Molecules (Basel, Switzerland) · 2024Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The toxic effects of different forms of nanomaterials comprise a series of biological effects such as oxidative stress; DNA damage; inflammatory response; activation of nuclear transcription factors. Some of these are key characteristics of human carcinogens and have been considered for hazard identification of nanomaterials. In addition, epigenetic changes also play a key role in the multi-step sequential process of carcinogenesis. Epigenetic modifications may constitute changes in DNA methylation, histone modifications (methylation, acetylation etc), and changes in non-coding RNA, leading to an altered gene expression profile. In this chapter, we describe the state-of-the-art of epigenetic modifications induced by different nanomaterials, from a limited number of in vitro- in vivo and human studies, a majority of which is primarily focused on DNA methylation. We also highlight the potential challenges and future directions in the field of epigenetics research in nanomaterial toxicology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.