Evidence map›Paper›PMID 35583321›Full record

ArticlemBio2022

Bacterial Quorum Sensing Allows Graded and Bimodal Cellular Responses to Variations in Population Density.

Jennifer B Rattray, Stephen A Thomas, Yifei Wang, Evgeniya Molotkova, James Gurney, John J Varga, Sam P Brown

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Breeding ofBiodesign research · 2026
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  18. Phenotypic memory in quorum sensing.PLoS computational biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jennifer B RattraySchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.ORCID 0000-0003-3478-2242
Stephen A ThomasSchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.
Yifei WangSchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.ORCID 0000-0002-7510-7959
Evgeniya MolotkovaSchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.
James GurneySchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.
John J VargaSchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.ORCID 0000-0002-4868-1971
Sam P BrownSchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.
Georgia Institute of Technology · US

Funding

Phages as drivers of pathogenicity: selective impacts and molecular targets of clinical Pseudomonas aeruginosa phagesR21AI143296 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI BROWN, SAMUEL PAUL, WHITELEY, MARVIN · 2019 to 2020
$434k
Building re-usable phage and antibiotic treatments via exploitation of bacteria-phage co-evolutionary dynamicsR21AI156817 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI BROWN, SAMUEL PAUL · 2021 to 2022
$434k
NIAID NIH HHS R21 AI143296NIAID NIH HHS R21 AI156817
6 · The paper itself

Abstract

Quorum sensing (QS) is a mechanism of cell-cell communication that connects gene expression to environmental conditions (e.g., cell density) in many bacterial species, mediated by diffusible signal molecules. Current functional studies focus on qualitatively distinct QS ON/OFF states. In the context of density sensing, this view led to the adoption of a "quorum" analogy in which populations sense when they are above a sufficient density (i.e., "quorate") to efficiently turn on cooperative behaviors. This framework overlooks the potential for intermediate, graded responses to shifts in the environment. In this study, we tracked QS-regulated protease (

Indexed as

Pseudomonas aeruginosaQuorum SensingBacteriaGene Expression Regulation, BacterialPopulation Densitybacterial communicationquorum sensingreaction normsociomicrobiology

Identifiers

PMID35583321
PMCPMC9239169
OpenAlexW4280499164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.