Evidence map›Paper›PMID 35583208›Full record

ArticleThe Journal of nutrition2022

A Classification System for Defining and Estimating Dietary Intake of Live Microbes in US Adults and Children.

Maria L Marco, Robert Hutkins, Colin Hill, Victor L Fulgoni, Christopher J Cifelli, Jaime Gahche, Joanne L Slavin, Daniel Merenstein, Daniel J Tancredi, Mary E Sanders

Registry-linked trialAbstract read
In one paragraph

Article in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06087146 (Sauerkraut Supplementation in Athletes for Gut Microbiome Optimization), which is not on this map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06087146 nacompletednot on this mapstarted 2023, after this paper: background citation

Sauerkraut Supplementation in Athletes for Gut Microbiome Optimization: Case Series and Literature Review (Project KOMS)

TypeinterventionalSponsorThe Gut Microbiome Center (Centar za crijevni mikrobiom)Ran2023 to 2023Enrolled10ConditionsGastrointestinal MicrobiomeArmsSauerkraut (Brassica oleracea v. capitata)
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The effects ofFrontiers in nutrition · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Association between dietary active microbe intake and dental caries among American adults : Evidence from the NHANES database.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
    Article
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  15. Development and Validation of a Food Frequency Questionnaire to Assess Fermented Food Consumption in Adults.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Daily dietary patterns associated withFrontiers in nutrition · 2026
    Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria L MarcoDepartment of Food Science and Technology, University of California Davis, Davis, CA, USA.
Robert HutkinsDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0003-1206-5947
Colin HillAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-8527-1445
Victor L FulgoniNutrition Impact, LLC, Battle Creek, MI, USA.ORCID 0000-0003-1569-8520
Christopher J CifelliNational Dairy Council, Rosemont, IL, USA.ORCID 0000-0002-8450-9650
Jaime GahcheOffice of Dietary Supplements, NIH, Bethesda, MD, USA.ORCID 0000-0002-1339-506X
Joanne L SlavinDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.ORCID 0000-0003-0720-5300
Daniel MerensteinDepartment of Family Medicine, Georgetown University School of Medicine, Washington, DC, USA.ORCID 0000-0002-8808-6907
Daniel J TancrediDepartment of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-3884-7907
Mary E SandersInternational Scientific Association for Probiotics and Prebiotics, Centennial, CO, USA.ORCID 0000-0001-6321-3423

Funding

Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studiesU01HL146205 · NHLBI · GEORGETOWN UNIVERSITY · PI SEBLE G KASSAYE, DANIEL J MERENSTEIN · 2019 to 2026
$23.5M
Understanding probiotic carrier format in the prevention of antibiotic-associated diarrhea - Murine Model SupplementR01HD088428 · NICHD · GEORGETOWN UNIVERSITY · PI MERENSTEIN, DANIEL J · 2017 to 2021
$3.6M
Yogurt beverages as a vehicle to deliver high dose probioticsU01AT003600 · NCCIH · GEORGETOWN UNIVERSITY · PI MERENSTEIN, DANIEL J · 2009 to 2013
$1.3M
Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for ProbioticsR61AT009622 · NCCIH · GEORGETOWN UNIVERSITY · PI FRASER, CLAIRE M., MERENSTEIN, DANIEL J · 2018 to 2019
$649k
The NOSES Trial, Nasal irrigation, Oral steroids, Antibiotics and Subgroup targetR34AI085193 · NIAID · GEORGETOWN UNIVERSITY · PI MERENSTEIN, DANIEL J · 2009 to 2009
$234k
NCCIH NIH HHS R61 AT009622NCCIH NIH HHS U01 AT003600NHLBI NIH HHS U01 HL146205NIAID NIH HHS R34 AI085193
6 · The paper itself

Abstract

backgroundConsuming live microbes in foods may benefit human health. Live microbe estimates have not previously been associated with individual foods in dietary databases.

objectivesWe aimed to estimate intake of live microbes in US children (aged 2-18 y) and adults (≥19 y) (n = 74,466; 51.2% female).

methodsUsing cross-sectional data from the NHANES (2001-2018), experts assigned foods an estimated level of live microbes per gram [low (Lo), <104 CFU/g; medium (Med), 104-107 CFU/g; or high (Hi), >107 CFU/g]. Probiotic dietary supplements were also assessed. The mean intake of each live microbe category and the percentages of subjects who ate from each live microbe category were determined. Nutrients from foods with live microbes were also determined using the population ratio method. Because the Hi category comprised primarily fermented dairy foods, we also looked at aggregated data for Med or Hi (MedHi), which included an expanded range of live microbe-containing foods, including fruits and vegetables.

resultsOur analysis showed that 52%, 20%, and 59% of children/adolescents, and 61%, 26%, and 67% of adults, consumed Med, Hi, or MedHi foods, respectively. Per capita intake of Med, Hi, and MedHi foods was 69, 16, and 85 g/d for children/adolescents, and 106, 21, and 127 g/d for adults, respectively. The proportion of subjects who consumed live microbes and overall per capita intake increased significantly over the 9 cycles/18-y study period (0.9-3.1 g/d per cycle in children across categories and 1.4 g/d per cycle in adults for the Med category).

conclusionsThis study indicated that children, adolescents, and adults in the United States steadily increased their consumption of foods with live microbes between the earliest (2001-2002) and latest (2017-2018) survey cycles. Additional research is needed to determine the relations between exposure to live microbes in foods and specific health outcomes or biomarkers.

Indexed as

DietVegetablesAdolescentAdultChildCross-Sectional StudiesEatingEnergy IntakeFemaleHumansMaleNutrition SurveysUnited Statesfermented foodInternational Scientific Association for Probiotics and PrebioticsISAPPlive dietary microbesNHANESprobiotics

Identifiers

PMID35583208
PMCPMC9258558

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.