ArticleGenetic epidemiology2022
Adjusting for collider bias in genetic association studies using instrumental variable methods.
Article in Genetic epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reassessing the association of MUC5B with survival in idiopathic pulmonary fibrosis.Annals of human genetics · 2023Pooled it
- Investigating the repurposing potential of immune checkpoint inhibition for cancer treatment using Mendelian randomisation.Research square · 2026Article
- Bayesian Mendelian randomization methods for index trait bias correction in subsequent trait genome-wide association studies.HGG advances · 2026Article
- Comparison of methods for assessing effects of risk factors on disease progression in Mendelian randomization under index event bias.American journal of human genetics · 2026Article
- Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.Journal of the American College of Cardiology · 2026Article
- Article
- Genetic evidence for causal relationships between brain functional networks and domain-specific recovery after nondisabling ischemic stroke.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression.European journal of human genetics : EJHG · 2025Article
- Getting to GRIPS with MR-Egger: Modelling directional pleiotropy independently of allele coding.PLoS genetics · 2025Article
- Investigating the association between anthropometry and colorectal cancer survival: a two-sample Mendelian randomization analysis.International journal of epidemiology · 2025Article
- The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases.American journal of human genetics · 2025Article
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.Molecular psychiatry · 2025Review
- Causal association of long COVID with brain structure changes: Findings from a 2-sample Mendelian randomization study.medRxiv : the preprint server for health sciences · 2025Article
- Estimating Causal Effects on a Disease Progression Trait Using Bivariate Mendelian Randomisation.Genetic epidemiology · 2025Article
- Systematic Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets for Functional Outcome After Ischemic Stroke.Journal of the American Heart Association · 2024Article
- Identification and correction for collider bias in a genome-wide association study of diabetes-related heart failure.American journal of human genetics · 2024Article
- The Application of Mendelian Randomization in Cardiovascular Disease Risk Prediction: Current Status and Future Prospects.Reviews in cardiovascular medicine · 2024Review
- Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression.European journal of epidemiology · 2024Article
- Adjusting for principal components can induce spurious associations in genome-wide association studies in admixed populations.bioRxiv : the preprint server for biology · 2024Article
- Collider bias correction for multiple covariates in GWAS using robust multivariable Mendelian randomization.PLoS genetics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Genome-wide association studies have provided many genetic markers that can be used as instrumental variables to adjust for confounding in epidemiological studies. Recently, the principle has been applied to other forms of bias in observational studies, especially collider bias that arises when conditioning or stratifying on a variable that is associated with the outcome of interest. An important case is in studies of disease progression and survival. Here, we clarify the links between the genetic instrumental variable methods proposed for this problem and the established methods of Mendelian randomisation developed to account for confounding. We highlight the critical importance of weak instrument bias in this context and describe a corrected weighted least-squares procedure as a simple approach to reduce this bias. We illustrate the range of available methods on two data examples. The first, waist-hip ratio adjusted for body-mass index, entails statistical adjustment for a quantitative trait. The second, smoking cessation, is a stratified analysis conditional on having initiated smoking. In both cases, we find little effect of collider bias on the primary association results, but this may propagate into more substantial effects on further analyses such as polygenic risk scoring and Mendelian randomisation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.