Evidence map›Paper›PMID 35583005›Full record

ArticleInternational journal of oncology2022

MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer.

Feng Geng, Wei Yang, Dandan Song, Haijia Hou, Bing Han, Yecheng Chen, Hongwen Zhao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Feng GengDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Wei YangDepartment of Pulmonary and Critical Care Medicine, General Hospital of Northern Theatre Command, Shenyang, Liaoning 110001, P.R. China.
Dandan SongDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Haijia HouDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Bing HanDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Yecheng ChenDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Hongwen ZhaoDepartment of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
China Medical University · CNFirst Hospital of China Medical University · CNGeneral Hospital of Shenyang Military Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have indicated that mineral dust‑induced gene (MDIG) is an oncogene induced by environmental factors, which has a key role in the development and progression of various tumor types, through epigenetic modifications; however, there are no previous pan‑cancer analyses of MDIG. In the present study, a comprehensive pan‑cancer analysis of MDIG was performed using public databases. The results demonstrated that MDIG was upregulated in tumor tissue samples compared with normal tissue, that it was present in all cancer cell lines and it was closely associated with the prognosis of patients with different tumor types. Furthermore, MDIG expression was closely associated with the immunological characteristics of the tumor microenvironment (TME), such as the frequency of tumor‑infiltrating immune cells, TME‑relevant signatures, immunostimulatory genes, immune checkpoint genes, chemokine receptor genes, tumor mutational burden and microsatellite instability. In parallel, high expression of MDIG was associated with improved overall survival of patients and this was verified in a cohort of patients who had received anti‑programmed cell death 1 ligand 1 treatment. Furthermore, high expression of MDIG led to multiple drug resistance in The Cancer Genome Atlas‑lung adenocarcinoma cohort. In addition, gene set variant analysis and gene set enrichment analysis indicated that MDIG was involved in cell cycle regulation.

Indexed as

Lung NeoplasmsOncogenesBiomarkers, TumorDioxygenasesHistone DemethylasesHumansKetoglutaric AcidsNuclear ProteinsOxygenasesPrognosisProto-Oncogene Proteins c-aktTumor MicroenvironmentBiomarkers, TumorDioxygenasesHistone DemethylasesKetoglutaric AcidsNuclear ProteinsOxygenasesProto-Oncogene Proteins c-aktRIOX2 protein, humanAKT signalingcell proliferationmineral dust‑induced genepan‑cancerprognostic and therapeutic biomarker

Identifiers

PMID35583005
PMCPMC9162052
OpenAlexW4280516547

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.