ArticleFoot & ankle international2022
Foot Osteomyelitis Location and Rates of Primary or Secondary Major Amputations in Patients With Diabetes.
Article in Foot & ankle international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Rationales for Antibiotic Treatment Versus Direct Surgical Resection in Various Strata of Diabetic Foot Osteomyelitis-Literature Review and Expert Opinions.Antibiotics (Basel, Switzerland) · 2026Article
- The acute diabetic foot: different clinical patterns with a dedicated fast-track pathway.Acta diabetologica · 2026Article
- Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review).International journal of molecular medicine · 2026Review
- Predicting limb amputation in trauma-related necrotizing fasciitis of the extremities: insights from a 10-year cohort.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Machine learning-based prediction of major amputation risk after initial limb-preserving surgery in diabetic foot.Frontiers in endocrinology · 2026Article
- Research status and trends of diabetic foot related osteomyelitis from 1994 to 2024: A 30-year bibliometric analysis.Medicine · 2025Article
- Osteomyelitis and Its Main Determinants in Patients With Diabetic Foot Ulcer: A Cross-Sectional Study.Health science reports · 2025Article
- Role of Biomarkers in Diabetic Foot Osteomyelitis.Journal of orthopaedic case reports · 2025Article
- Outcome of diabetic foot ulcers at a Tertiary Care Foot Centre in Pakistan.International wound journal · 2025Article
- The Use of Platelet-Rich Fibrin-Coated Three-Dimensionally (3D) Printed Scaffolds in Salvage of Complex Hindfoot Cases.Biomimetics (Basel, Switzerland) · 2025Article
- CLOSE-UP - a favourable protocol for limb-sparing surgery of diabetic foot osteomyelitis.Journal of bone and joint infection · 2025Article
- Practical guidelines for the prevention and management of diabetic foot disease in China.Burns & trauma · 2025Article
- Machine Learning Algorithm-Aided Determination of Predictors of Mortality from Diabetic Foot Sepsis at a Regional Hospital in South Africa During the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2024Article
- [Development and Validation of a Risk Prediction Model for Prolonged Hospitalization in Patients With Diabetic Foot Ulcers].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Surgical management of the diabetic foot: The current evidence.World journal of orthopedics · 2024Review
- Investigation and management of diabetic foot osteomyelitis: An update for the foot and ankle orthopaedic surgeon.Journal of clinical orthopaedics and trauma · 2024Article
- Racial and Ethnic Disparities in the Management of Diabetic Feet.Current reviews in musculoskeletal medicine · 2023Review
- Detection, management, and prevention of diabetes-related foot disease in the Australian context.World journal of diabetes · 2023Review
- Local Antibiotics in the Treatment of Diabetic Foot Infections: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Current knowledge of morbidities and direct costs related to diabetic foot disorders: a literature review.Frontiers in endocrinology · 2023Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic foot osteomyelitis (DFO) often leads to amputations in the lower extremity. Data on the influence of the initial anatomical DFO localization on ultimate major amputation are limited.
methodsIn this retrospective analysis, 583 amputation episodes in 344 patients (78 females, 266 males) were analyzed. All received a form of amputation in combination with antibiotic therapy. A multivariate logistic regression analysis with the primary outcome "major amputation" defined as an amputation above the ankle joint was performed. The association of risk factors including location of DFO, coronary artery disease, peripheral artery disease, neuropathy, nephropathy, and Charcot neuro-osteoarthropathy was analyzed.
resultsAmong 583 episodes, DFO was located in the forefoot in 512 (87.8%), in the midfoot in 43 (7.4%), and in the hindfoot in 28 episodes (4.8%). Overall, 53 of 63 (84.1%) major amputations were performed because of DFO in the setting of peripheral artery disease as primary indication. Overall, limb loss occurred in 6.1% (31/512) of forefoot, 20.9% (9/43) of midfoot, and 46.4% (13/28) of hindfoot DFO. Among these, 22 (41.5%) were performed as the primary treatment, whereas 31 (58.5%) followed previously failed minor amputations. Among this latter group of secondary major amputations, the DFO was localized to the forefoot in 23 of 583 (3.9%), the midfoot in 4 of 583 (0.7%) and the hindfoot in 4 of 583 (0.7%). In multivariate logistic regression analysis, initial hindfoot localization was a significant factor (
conclusionIn our retrospective series, the frequency of limb loss in DFO increased with more proximal initial foot DFO lesions, with almost half of patients losing their limbs with a hindfoot DFO. LEVEL OF EVIDENCE: Level IV, retrospective cohort study.
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