Evidence map›Paper›PMID 35582875›Full record

Trial reportJournal of viral hepatitis2022

Randomized clinical trial: Direct-acting antivirals as treatment for hepatitis C in people who inject drugs: Delivered in needle and syringe programs via directly observed therapy versus fortnightly collection.

Lewis Beer, Sarah Inglis, Amy Malaguti, Christopher Byrne, Christian Sharkey, Emma Robinson, Kirsty Gillings, Andrew Radley, Adrian Hapca, Brian Stephens and 1 more

Open access · hybridAbstract readRandomized Controlled TrialEquivalence Trial
In one paragraph

Trial report in Journal of viral hepatitis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Lewis BeerTayside Clinical Trials Unit, University of Dundee, Dundee, UK.
Sarah InglisTayside Clinical Trials Unit, University of Dundee, Dundee, UK.
Amy MalagutiTayside Drug & Alcohol Recovery Psychology Service, NHS Tayside, Dundee, UK.
Christopher ByrneTayside Clinical Trials Unit, University of Dundee, Dundee, UK.
Christian SharkeyNinewells Hospital and Medical School, NHS Tayside, Dundee, Scotland.
Emma RobinsonDepartment of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
Kirsty GillingsPsychology Department, NHS Fife, Cupar, UK.
Andrew RadleyDepartment of Public Health, NHS Tayside, Dundee, UK.
Adrian HapcaTayside Clinical Trials Unit, University of Dundee, Dundee, UK.
Brian StephensNinewells Hospital and Medical School, NHS Tayside, Dundee, Scotland.
John DillonDepartment of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
NHS Tayside · GBFife Council · GBNinewells Hospital · GBUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) treatment in people who inject drugs (PWID) is delivered within settings frequented by PWID, such as needle and syringe programs (NSP). The optimal direct-acting antiviral (DAA) dispensing regimen among NSP clients is unknown. This study compared cures (Sustained virologic response 12 weeks post-treatment, [SVR

Indexed as

Drug UsersHepatitis CHepatitis C, ChronicSubstance Abuse, IntravenousAntiviral AgentsDirectly Observed TherapyHepacivirusHumansSyringesAntiviral Agentsdirect-acting antiviralshepatitis cneedle and syringe programsrandomized controlled trial

Identifiers

PMID35582875
PMCPMC9544056
OpenAlexW4280538342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.