Evidence map›Paper›PMID 35582804›Full record

ArticleProceedings. Biological sciences2022

Local mechanical stimuli correlate with tissue growth in axolotl salamander joint morphogenesis.

Ester Comellas, Johanna E Farkas, Giona Kleinberg, Katlyn Lloyd, Thomas Mueller, Timothy J Duerr, Jose J Muñoz, James R Monaghan, Sandra J Shefelbine

Open access · greenAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Mechanosignaling in Osteoporosis: When Cells Feel the Force.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
  4. Material properties in regenerating axolotl limbs using inverse finite element analysis.Journal of the mechanical behavior of biomedical materials · 2024
    Article
  5. Article
  6. Article
  7. Open biology · 2022
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ester ComellasSerra Húnter Fellow, Department of Physics, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain.ORCID 0000-0002-3981-2634
Johanna E FarkasDepartment of Biology, Northeastern University, Boston, MA USA.ORCID 0000-0001-6540-7870
Giona KleinbergDepartment of Bioengineering, Northeastern University, Boston, MA USA.ORCID 0000-0002-6900-0215
Katlyn LloydDepartment of Bioengineering, Northeastern University, Boston, MA USA.
Thomas MuellerDepartment of Bioengineering, Northeastern University, Boston, MA USA.
Timothy J DuerrDepartment of Biology, Northeastern University, Boston, MA USA.ORCID 0000-0002-4945-0294
Jose J MuñozDepartment of Mathematics, Laboratori de Càlcul Numeric (LaCàN), Universitat Politècnica de Catalunya (UPC), Barcelona, Spain.ORCID 0000-0002-0083-3673
James R MonaghanDepartment of Biology, Northeastern University, Boston, MA USA.ORCID 0000-0002-6689-6108
Sandra J ShefelbineDepartment of Mechanical and Industrial Engineering, Northeastern University, Boston, MA USA.ORCID 0000-0002-4011-9044
Northeastern University · USInternational Center for Numerical Methods in Engineering · ES

Funding

Ambystoma Genetic Stock Center - Revision to Include Curation and Informatics ComponentP40OD019794 · OD · UNIVERSITY OF KENTUCKY · PI Stephen Randal Voss · 2015 to 2026
$6.3M
Mechanisms of skeletal patterning during limb development and regenerationR01HD099174 · NICHD · NORTHEASTERN UNIVERSITY · PI MONAGHAN, JAMES R · 2020 to 2024
$1.6M
NICHD NIH HHS R01 HD099174NIH HHS P40 OD019794
6 · The paper itself

Abstract

Movement-induced forces are critical to correct joint formation, but it is unclear how cells sense and respond to these mechanical cues. To study the role of mechanical stimuli in the shaping of the joint, we combined experiments on regenerating axolotl (

Indexed as

Ambystoma mexicanumCaudataAnimalsForelimbMorphogenesisTRPV Cation ChannelsTRPV Cation Channelscartilage growthcartilage mechanosensitivityporoelasticitysynovial joint developmenttransient receptor potential vanilloid 4

Identifiers

PMID35582804
PMCPMC9114971
OpenAlexW4280542077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.