Evidence map›Paper›PMID 35582670›Full record

SynthesisWorld journal of gastroenterology2022

Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum: A case series and systematic literature review.

Michael T LeCompte, Brandon Mason, Keenan J Robbins, Motoyo Yano, Deyali Chatterjee, Ryan C Fields, Steven M Strasberg, William G Hawkins

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

  1. Analysis of CT and MRI imaging features of ectopic pancreas.Quantitative imaging in medicine and surgery · 2026
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  10. Bleeding duodenal ectopic pancreas: laparoscopic case report.Annals of medicine and surgery (2012) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Michael T LeCompteDepartment of Surgical Oncology, University of North Carolina, Raleigh, NC 27608, United States. mtleco01@gmail.com.
Brandon MasonDepartment of Radiology, Stillwater Medical Center, Stillwater, OK 74074, United States.
Keenan J RobbinsDepartment of General Surgery, Washington University St. Louis, St. Louis, MO 63110-8109, United States.
Motoyo YanoDepartment of Radiology, Mayo Clinic, Phoenix, AZ 8505, United States.
Deyali ChatterjeeDepartment of Pathology and Immunology, MD Anderson Cancer Center, Houston, TX 77030, United States.
Ryan C FieldsDepartment of Surgical Oncology, Washington University School of Medicine, St. Louis, MO 63110-8109, United States.
Steven M StrasbergSection of Hepatobiliary-Pancreatic and GI Surgery, Washington University St. Louis, St. Louis, MO 63110, United States.
William G HawkinsSection of Hepatobiliary-Pancreatic and GI Surgery, Washington University St. Louis, St. Louis, MO 63110, United States.
Washington University in St. Louis · USMayo Clinic Hospital · USNorth Carolina State University · USOklahoma State University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

backgroundHeterotopic pancreas (HP) is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract. While the majority of heterotopic pancreatic lesions are asymptomatic, many manifest severe clinical symptoms which require surgical or endoscopic intervention. Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature. The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.

aimTo classify the common clinical manifestations of heterotopic pancreas.

methodsA retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018. Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location. Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated. These were compared to a systematic review of the literature utilizing PubMed and Embase searches for papers pertaining to heterotopic pancreas. Publications describing symptomatic presentation of HP were selected for review. Information including demographics, symptoms, presentation and treatment were compiled and analyzed.

resultsTwenty-nine patient were identified with HP at a single center, with six of these identified has having clinical symptoms. Clinical manifestations included, gastrointestinal bleeding, gastric ulceration with/without perforation, pancreatitis, and gastric outlet obstruction. Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients. Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients. The majority of patients presented with abdominal pain (67%) combined with one of the following clinical categories: (1) Dyspepsia, (

conclusionHeterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract. Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation.

Indexed as

ChoristomaGastric Outlet ObstructionPancreatitisUpper Gastrointestinal TractDuodenumGastrointestinal HemorrhageHumansPancreasAberrant pancreasEctopic pancreasGroove pancreatitisHeterotopic pancreasPancreatic rest

Identifiers

PMID35582670
PMCPMC9048474
OpenAlexW4226063869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.