Evidence map›Paper›PMID 35582633›Full record

ArticleJournal of King Saud University. Science2022

Computational studies on potential new anti-Covid-19 agents with a multi-target mode of action.

Ranjan K Mohapatra, Mohammad Azam, Pranab K Mohapatra, Ashish K Sarangi, Mohnad Abdalla, Lina Perekhoda, Oval Yadav, Saud I Al-Resayes, Kim Jong-Doo, Kuldeep Dhama and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of King Saud University. Science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

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  12. Ethnomedicinal values ofFrontiers in chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

Ranjan K MohapatraDepartment of Chemistry, Government College of Engineering, Keonjhar, Odisha 758002, India.
Mohammad AzamDepartment of Chemistry, College of Science, King Saud University, PO BOX 2455, Riyadh 11451, Saudi Arabia.
Pranab K MohapatraDepartment of Chemistry, C. V. Raman Global University, Bidyanagar, Mahura, Janla, Bhubaneswar, Odisha 752054, India.
Ashish K SarangiDepartment of Chemistry, School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Mohnad AbdallaKey Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Shandong Province 250012, PR China.
Lina PerekhodaDepartment of Medicinal Chemistry, National University of Pharmacy, Pushkinska Str. 53, Kharkiv 61002, Ukraine.
Oval YadavDepartment of Chemistry, Central University of Haryana, Mahendergarh, Haryana 123031, India.
Saud I Al-ResayesDepartment of Chemistry, College of Science, King Saud University, PO BOX 2455, Riyadh 11451, Saudi Arabia.
Kim Jong-DooBuddhist Culture College, Dongguk University, Gyeongju-si, Gyeongsangbuk-do 780-714, South Korea.
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India.
Azaj AnsariDepartment of Chemistry, Central University of Haryana, Mahendergarh, Haryana 123031, India.
Veronique SeidelNatural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom.
Sarika VermaCouncil of Scientific and Industrial Research-Advanced Materials and Processes Research Institute, Bhopal, MP 462026, India.
Mukesh K RavalDepartment of Chemistry, G. M. University, Sambalpur, Odisha, India.
Central University of Haryana · INKing Saud University · SACenturion University of Technology and Management · INCouncil of Scientific and Industrial Research · INDongguk University · KRGovernment College of Engineering, KeonjharIndian Veterinary Research Institute · INNational University of Pharmacy · UASambalpur University · INShandong University · CNUniversity of Strathclyde · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A compound that could inhibit multiple targets associated with SARS-CoV-2 infection would prove to be a drug of choice against the virus. Human receptor-ACE2, receptor binding domain (RBD) of SARS-CoV-2 S-protein, Papain-like protein of SARS-CoV-2 (PLpro), reverse transcriptase of SARS-CoV-2 (RdRp) were chosen for in silico study. A set of previously synthesized compounds (

Indexed as

Drug-likeness predictionFrontiers molecular orbitalMolecular dockingMolecular dynamicsMolecular electrostatic potentialNatural bond orbitalPharmacokineticsSARS-CoV-2

Identifiers

PMID35582633
PMCPMC9101701
OpenAlexW4280596686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.