ArticleJournal of veterinary research2022
Genetic and Pathogenic Characterisation of a Virulent Akabane Virus Isolated from Goats in Yunnan, China.
Article in Journal of veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Mosquito- and biting-midge-borne arboviruses in Western Yunnan's border region, China.Parasites & vectors · 2026Article
- Genetic evolution of Akabane virus isolates and the protective efficacy of inactivated vaccines.Virology journal · 2025Article
- Pathogenicity analysis of a Chinese Genogroup II Akabane virus strain (TJ2016) in mouse models.Virology journal · 2025Article
- Factors influencing Akabane virus seroprevalence in sheep and goats in Egypt's Nile Delta.Tropical animal health and production · 2025Article
- Searching for potential Culicoides vectors of four orbiviruses in Yunnan Province, China.Parasites & vectors · 2025Article
- Genetic diversity and variation among Akabane virus field isolates from goats in Yunnan, China.Frontiers in veterinary science · 2025Article
- Whole-Genome Sequencing and Structure Study of Three Biting-Insect-Associated Viruses (Advances in virology · 2025Article
- Research progress on the N gene of Akabane virus.Frontiers in veterinary science · 2025Review
- Phylogenetic analysis and biological characteristics of an Akabane virus isolated in China.Frontiers in veterinary science · 2025Article
- Isolation and identification of an AKAV strain in dairy cattle in China.Frontiers in veterinary science · 2025Article
- Akabane virus isolated from biting midges and its infection in local domestic animal, Yunnan, China: a field and laboratory investigation.Frontiers in cellular and infection microbiology · 2024Article
- Isolation and characterization of Akabane virus Ib substrain and its pathogenesis in sulking mice.Virologica Sinica · 2023Article
- The First Serological Detection and Risk Factors Analysis of Akabane Virus in Egyptian Cattle.Animals : an open access journal from MDPI · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Akabane virus (AKAV) has been detected in a variety of host species in China, but there are only limited records of its occurrence in goats. However, more attention needs to be paid to understanding the diversity of viruses in this species. The aim of the study was to explore the genotype characteristics and variation trend of AKAV and their relationship with virulence in Yunnan, China. Material and Methods: Blood samples were collected from goats during routine surveillance of goat diseases in Yunnan province in 2019. The AKAV CX-01 strain was isolated using BHK-21 cells. To understand pathogenicity, the virus was intraperitoneally (IP) and intracerebrally (IC) inoculated into suckling mice and tissue samples were subsequently analysed histopathologically and immunohistochemically. Results: Akabane virus CX-01 strain induced encephalitis and impairment of the central nervous system with fatal consequences. Phylogenetic analysis based on the ORF sequences of the small segments indicated that the AKAV isolate used was most closely related to the GD18134/2018 Chinese midge and bovine NM BS/1strains, while phylogenetic analysis based on the medium segments showed a close relationship between CX-01 and the Chinese GLXCH01 strain. Conclusion: The CX-01 isolate was related to AKAV genogroup Ia and probably originated from a recombination of different strains.
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