Evidence map›Paper›PMID 35582414›Full record

ArticleInternational journal of medical sciences2022

Blood biomarkers in early bacterial infection and sepsis diagnostics in feverish young children.

Algirdas Dagys, Goda Laucaitytė, Augusta Volkevičiūtė, Silvijus Abramavičius, Rimantas Kėvalas, Astra Vitkauskienė, Lina Jankauskaitė

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Biomarkers to guide sepsis management.Annals of intensive care · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Algirdas DagysLithuanian University of Health Sciences, Medical Academy, Department of Pediatrics, 50161 Kaunas, Lithuania.
Goda LaucaitytėLithuanian University of Health Sciences, Medical Academy, Department of Pediatrics, 50161 Kaunas, Lithuania.
Augusta VolkevičiūtėLaboratory of Preclinical Drug Investigation, Institute of Cardiology, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.
Silvijus AbramavičiusLaboratory of Preclinical Drug Investigation, Institute of Cardiology, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.
Rimantas KėvalasLithuanian University of Health Sciences, Medical Academy, Department of Pediatrics, 50161 Kaunas, Lithuania.
Astra VitkauskienėLithuanian University of Health Sciences, Medical Academy, Department of Pediatrics, 50161 Kaunas, Lithuania.
Lina JankauskaitėLithuanian University of Health Sciences, Medical Academy, Department of Pediatrics, 50161 Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesWhile most feverish children have self-limiting diseases, 5-10% develop a serious and potentially life-threatening bacterial infection (BI). Due to potential risk, prompt recognition of BI and sepsis in the pediatric emergency department (PED) remains a clinical priority. The aim of the study was to evaluate the role of certain cytokines and chemokines separately and in combination with routine blood tests in early BI and sepsis diagnostics at PED. MATERIALS AND

methodsWe prospectively studied children younger than 5 presenting to the PED with fever lasting for under 12 hours with high risk for serious illness. Clinical data, routine blood analysis, and inflammatory cytokine and chemokine panels were evaluated for their diagnostic abilities. Two separate analyses were carried out on the patients' data: one contrasting BI and viral infection (VI) groups, the other comparing septic and non-septic patients.

resultsThe sample comprised 70 patients (40% with BI). IL-2 was found to be the most specific biomarker to identify BI with specificity of 100%. The best discriminative ability was demonstrated by combining IL-2, IL-6, CRP, WBC, and neutrophil count: AUC 0.942 (95% Cl 0.859-0.984). IL-10 exhibited a greater AUC (0.837. 95% CI: 0.730-0.915 p<0.05) than CRP (0.807. 95% CI: 0.695-0.895 p<0.05) when predicting sepsis and showed high specificity (98%) and moderate sensitivity (75%).

conclusionsIL-6 and IL-2 could increase the diagnostic ability of routine blood tests for predicting BI, as IL-10 raises specificity for recognizing sepsis in the early hours of disease onset.

Indexed as

Bacterial InfectionsSepsisBiomarkersChildChild, PreschoolC-Reactive ProteinFeverHumansInterleukin-10Interleukin-2Interleukin-6BiomarkersC-Reactive ProteinInterleukin-10Interleukin-2Interleukin-6blood biomarkerschemokinecytokinepediatric emergency departmentsepsis, bacterial infection

Identifiers

PMID35582414
PMCPMC9108404
OpenAlexW4285164744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.