Evidence map›Paper›PMID 35582296›Full record

ReviewWorld journal of hepatology2022

Renal manifestations of hepatitis E among immunocompetent and solid organ transplant recipients.

Karthik Kovvuru, Nicholas Carbajal, Abhinandan Reddy Pakanati, Charat Thongprayoon, Panupong Hansrivijit, Boonphiphop Boonpheng, Pattharawin Pattharanitima, Voravech Nissaisorakarn, Wisit Cheungpasitporn, Swetha R Kanduri

Abstract readReview
In one paragraph

Review in World journal of hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Trial
  2. Article
  3. Review
  4. Article
  5. Hepatitis E infection: A review.World journal of virology · 2023
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karthik KovvuruDepartment of Medicine, Ochsner Clinic Foundation, New Orleans, LA 70121, United States.
Nicholas CarbajalDepartment of Medicine, Ochsner Clinic Foundation, New Orleans, LA 70121, United States.
Abhinandan Reddy PakanatiDepartment of Medicine, The Kidney Clinic LLC, Snellville, GA 30078, United States.
Charat ThongprayoonDepartment of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, United States.
Panupong HansrivijitDepartment of Internal Medicine, UPMC Pinnacle, Harrisburg, PA 17104, United States.
Boonphiphop BoonphengDepartment of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States.
Pattharawin PattharanitimaDepartment of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12121, Thailand.
Voravech NissaisorakarnDepartment of Internal Medicine, MetroWest Medical Center, Tufts University School of Medicine, Boston, MA 01760, United States.
Wisit CheungpasitpornDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, United States. wcheungpasitporn@gmail.com.
Swetha R KanduriDepartment of Medicine, Ochsner Clinic Foundation, New Orleans, LA 70121, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) infections are generally self-limited. Rare cases of hepatitis E induced fulminant liver failure requiring liver transplantation are reported in the literature. Even though HEV infection is generally encountered among developing countries, a recent uptrend is reported in developed countries. Consumption of unprocessed meat and zoonosis are considered to be the likely transmission modalities in developed countries. Renal involvement of HEV generally holds a benign and self-limited course. Although rare cases of cryoglobulinemia are reported in immunocompetent patients, glomerular manifestations of HEV infection are frequently encountered in immunocompromised and solid organ transplant recipients. The spectrum of renal manifestations of HEV infection include pre-renal failure, glomerular disorders, tubular and interstitial injury. Kidney biopsy is the gold standard diagnostic test that confirms the pattern of injury. Management predominantly includes conservative approach. Reduction of immunosuppressive medications and ribavirin (for 3-6 mo) is considered among patients with solid organ transplants. Here we review the clinical course, pathogenesis, renal manifestations, and management of HEV among immunocompetent and solid organ transplant recipients.

Indexed as

Acute kidney injuryGlomerular disordersHepatitis EKidney biopsyKidney transplantSolid organ transplant

Identifiers

PMID35582296
PMCPMC9055200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.