Evidence map›Paper›PMID 35582283›Full record

ReviewCancer drug resistance (Alhambra, Calif.)2019

Relationship between ovarian cancer stem cells, epithelial mesenchymal transition and tumour recurrence.

Monica Angelica Amaya Padilla, Mudra Binju, Graeme Wan, Yohan Suryo Rahmanto, Pritinder Kaur, Yu Yu

Open access · diamondAbstract readReview
In one paragraph

Review in Cancer drug resistance (Alhambra, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. CD133 Act as an Essential Marker in Ovarian Carcinogenesis.Asian Pacific journal of cancer prevention : APJCP · 2021
    Article
  8. KLF7: a new candidate biomarker and therapeutic target for high-grade serous ovarian cancer.Journal of experimental & clinical cancer research : CR · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Monica Angelica Amaya PadillaSchool of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia.
Mudra BinjuSchool of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia.
Graeme WanSchool of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia.
Yohan Suryo RahmantoSidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Pritinder KaurSchool of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia.
Yu YuSchool of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia.
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Investigating the biological processes that occur to enable recurrence and the development of chemoresistance in ovarian cancer is critical to the research and development of improved treatment options for patients. The lethality of ovarian cancer is largely attributed to the recurrence of disease with acquired chemoresistance. Cancer stem cells are likely to be critical in ovarian cancer progression, contributing to tumour malignancy, metastasis and recurrence by persisting in the body despite treatment with anti-cancer drugs. Moreover, cancer stem cells are capable of mediating epithelial-to-mesenchymal transition traits and secrete extracellular vesicles to acquire therapy resistance and disease dissemination. These attributes merit in depth research to provide insight into the biological role of ovarian cancer stem cells in disease progression and chemotherapy response, leading to the development of improved biomarkers and innovative therapeutic approaches.

Indexed as

chemoresistanceepithelial-to-mesenchymal transitionextracellular vesiclesOvarian cancerplatinum resistancerecurrencestem cells

Identifiers

PMID35582283
PMCPMC9019200
OpenAlexW2996421278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.