Evidence map›Paper›PMID 35582127›Full record

ReviewWorld journal of gastroenterology2022

Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection.

Jiyoung Yoon, Seung-Yeon Yoo, Young Soo Park, Kee Don Choi, Beom Su Kim, Moon-Won Yoo, In Seob Lee, Jeong Hwan Yook, Ga Hee Kim, Hee Kyong Na and 7 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Endoscopic Submucosal Dissection for Early Gastric Cancer: Current Standard Indication and Management.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Early Gastric Cancer: Update on Prevention, Diagnosis and Treatment.International journal of environmental research and public health · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Jiyoung Yoon-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Seung-Yeon YooDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Young Soo ParkDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Kee Don Choi-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea. keedon@amc.seoul.kr.
Beom Su KimDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Moon-Won YooDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
In Seob LeeDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Jeong Hwan YookDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Ga Hee Kim-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Hee Kyong Na-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Ji Yong Ahn-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Jeong Hoon Lee-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Kee Wook Jung-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Do Hoon Kim-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Ho June Song-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Gin Hyug Lee-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Hwoon-Yong Jung-Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
University of Ulsan · KRUlsan College · KRAsan Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the criteria for the indication of endoscopic submucosal dissection (ESD) for undifferentiated early gastric cancer (UD-EGC) have been recently proposed, accumulating reports on the non-negligible rate of lymph node metastasis (LNM) after indicated ESD raise questions on the reliability of the current criteria.

aimTo investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for ESD.

methodsWe retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center, a tertiary university hospital in Korea. To identify the risk factors of LNM of UD-EGC meeting the expanded criteria for ESD, we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:4. We reviewed the clinical, endoscopic, and histologic features of the cases to identify features with a significant difference according to the presence of LNM. Univariate and multivariate logistic regression analyses were performed to estimate the odds ratios (ORs).

resultsOf the 4780 UD-EGC cases, 1240 (25.9%) were identified to meet the expanded indication for ESD. Of the 1240 cases, 14 (1.1%) cases had LNM. Among the various clinical, endoscopic, and histopathological features that were evaluated, mixed histology (tumors consisting of 10%-90% of signet ring cells) had a marginally significant association (

conclusionThe risk of LNM is higher than expected when using the current expanded indication for UD-EGC. Histological evaluation could provide useful clues for reducing the risk of LNM.

Indexed as

Endoscopic Mucosal ResectionStomach NeoplasmsCase-Control StudiesGastrectomyGastric MucosaHumansLymphatic MetastasisReproducibility of ResultsRetrospective StudiesRisk FactorsEndoscopic submucosal dissectionGastric cancerLymph node metastasisUndifferentiated carcinoma

Identifiers

PMID35582127
PMCPMC9048457
OpenAlexW4223958804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.