Evidence map›Paper›PMID 35581745›Full record

ArticlePhysiological reports2022

SPLUNC1 is a negative regulator of the Orai1 Ca

Tongde Wu, Alexandra S Goriounova, Erin N Worthington, Joe A Wrennall, Arunava Ghosh, Saira Ahmad, M Flori Sassano, Robert Tarran

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Orai1 acts as a novel CaExperimental & molecular medicine · 2026
    Article
  2. Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025
    Review
  3. Review
  4. ENaC contributes to macrophage dysfunction in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tongde WuDepartment of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.
Alexandra S GoriounovaDepartment of Pharmacology, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.ORCID 0000-0002-2180-3211
Erin N WorthingtonDivison of Pulmonology, Department of Pediatrics, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.
Joe A WrennallDepartment of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.
Arunava GhoshDepartment of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.
Saira AhmadDepartment of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.
M Flori SassanoDepartment of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.
Robert TarranDepartment of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, North Carolina, 27599, USA.
University of North Carolina at Chapel Hill · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
TRAINING IN RESPIRATORY AND ENVIRONMENTAL MEDICINET32HL007106 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES, DOERSCHUK, CLAIRE M · 1985 to 2021
$7.3M
Pathogenesis of ozone-induced asthma exacerbationR01ES025198 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TILLEY, STEPHEN LLOYD · 2015 to 2019
$1.7M
SPLUNC1-Derived Peptides as ENaC AntagonistsR01HL108927 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TARRAN, ROBERT · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL108927NHLBI NIH HHS T32 HL007106NIDDK NIH HHS P30 DK065988NIEHS NIH HHS R01 ES025198
6 · The paper itself

Abstract

Orai1 is a ubiquitously-expressed plasma membrane Ca

Indexed as

LungMuscle, SmoothCalciumCalcium SignalingCell MembraneGlycoproteinsHEK293 CellsHumansORAI1 ProteinPhosphoproteinsBPIFA1 protein, humanCalciumGlycoproteinsORAI1 ProteinORAI1 protein, humanPhosphoproteinsairwayairway smooth muscleBPIFA1calciumFRETNEDD4-2

Identifiers

PMID35581745
PMCPMC9114653
OpenAlexW4280527821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.