Evidence map›Paper›PMID 35581660›Full record

Trial reportBMC palliative care2022

Carer preferences of route of administration of transmucosal diamorphine and willingness to take part in a randomised controlled trial: an interview study (DIPPER).

Liz Jamieson, Emily Harrop, Christina Liossi, Katherine Boyce, Lorraine Mitchell, Margaret Johnson, Yogini Jani, Victoria Akinyooye, Simon S Skene, Ian C K Wong and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC palliative care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Liz JamiesonCentre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust & UCL School of Pharmacy, London, UK. e.jamieson@ucl.ac.uk.ORCID http://orcid.org/0000-0002-3667-0423
Emily HarropHelen and Douglas House Hospice, Oxford, UK.ORCID http://orcid.org/0000-0002-2480-2062
Christina LiossiSchool of Psychology, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.ORCID http://orcid.org/0000-0003-0627-6377
Katherine BoyceHelen and Douglas House Hospice, Oxford, UK.
Lorraine MitchellGreat Ormond Street Hospital Children's Charity, London, UK.
Margaret JohnsonPatient and Public Representative C/o Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Yogini JaniCentre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust & UCL School of Pharmacy, London, UK.ORCID http://orcid.org/0000-0001-5927-5429
Victoria AkinyooyeCentre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust & UCL School of Pharmacy, London, UK.
Simon S SkeneSurrey Clinical Trials Unit, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-7828-3122
Ian C K WongCentre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust & UCL School of Pharmacy, London, UK.ORCID http://orcid.org/0000-0001-8242-0014
Richard F HowardGreat Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0001-9271-0074
Kate OultonGreat Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-5778-3849
University College London Hospitals NHS Foundation Trust · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBGreat Ormond Street Hospital Children's Charity · GBUniversity of Cambridge · GBUniversity of Southampton · GBUniversity of Surrey · GB

Funding

Research for Patient Benefit Programme PB-PG-0317-20036
6 · The paper itself

Abstract

backgroundChildren and young people are usually given liquid morphine by mouth for breakthrough pain, which can take thirty minutes to work. A faster-acting, quickly absorbed, needle-free pain medicine, that is easy to administer is needed such as transmucosal (sublingual, buccal, intranasal) diamorphine. Research evidence relating to the administration of medication for breakthrough pain in children and young people is limited. This study aims to describe the experiences and preferences of parents and/or children and young people regarding the route of administration of diamorphine, barriers and facilitators comparative to oral morphine, and participation in a randomised controlled trial.

methodsIn-depth, semi-structured interviews with parents and/or children and young people at home or hospital/hospice.

resultsThirteen interviews with: nine mothers, one father, and three sets of parents jointly. No interviews took place with a child/young person. Most families had experience of the buccal route which was effective in ease of administration and time to control pain. The intranasal route was preferred by parents irrespective of experience. Parents' willingness for their child to take part in a trial depended on the time commitment, their child's pain trajectory and the stability of analgesic requirements.

conclusionA randomised controlled trial of oral morphine versus transmucosal diamorphine would need to consider trial logistics, especially time commitment. Parents felt that the trial should be introduced initially by the clinical team, with written information from the research team, and sufficient time to ask questions. Patients who had discontinued oral morphine because of side effects, or those with gastrointestinal failure, should be excluded. Maintaining stability in pain management was essential to families, so the timing of the trial is a potential issue.

Indexed as

Breakthrough PainHeroinAdolescentAnalgesics, OpioidCaregiversChildHumansMorphineQualitative ResearchAnalgesics, OpioidHeroinMorphineBreakthrough painDiamorphineOpioidsPaediatricsPain managementPalliative careTerminal care

Identifiers

PMID35581660
PMCPMC9110942
OpenAlexW4280579405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.