Evidence map›Paper›PMID 35581528›Full record

ArticleAlcoholism, clinical and experimental research2022

The impact of prenatal alcohol exposure on gray matter volume and cortical surface area of 2 to 3-year-old children in a South African birth cohort.

Sivenesi Subramoney, Shantanu H Joshi, Catherine J Wedderburn, David Lee, Annerine Roos, Roger P Woods, Heather J Zar, Katherine L Narr, Dan J Stein, Kirsten A Donald

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Sivenesi SubramoneyDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-8947-439X
Shantanu H JoshiDepartment of Neurology, University of California Los Angeles, Los Angeles, California, USA.
Catherine J WedderburnDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
David LeeDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California, USA.
Annerine RoosDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Roger P WoodsDepartments of Neurology, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Katherine L NarrDepartments of Neurology, Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Dan J SteinThe Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Kirsten A DonaldDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
University of California, Los Angeles · USUniversity of Cape Town · ZASouth African Medical Research Council · ZA

Funding

Cross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1M
Tracking and Prediction of Early Brain-Face Biomarkers of Prenatal Alcohol Exposure from Neonates to ChildrenR01AA026834 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kirsty Donald, Shantanu H. Joshi · 2018 to 2026
$3.8M
A neuroimaging study of 2 year old children with alcohol exposure compared to healthy unexposed controls embedded in a birth cohort studyR21AA023887 · NIAAA · UNIVERSITY OF CAPE TOWN · PI DONALD, KIRSTY · 2016 to 2017
$280k
NIAAA NIH HHS R01 AA026834NIAAA NIH HHS R21 AA023887NIAAA NIH HHS U24 AA014811Wellcome Trust
6 · The paper itself

Abstract

backgroundThere is a growing literature that demonstrates the effects of prenatal alcohol exposure (PAE) on brain development in school-aged children. Less is known, however, on how PAE impacts the brain early in life. We investigated the effects of PAE and child sex on subcortical gray matter volume, cortical surface area (CSA), cortical volume (CV), and cortical thickness (CT) in children aged 2 to 3 years.

methodsThe sample was recruited as a nested cross-sectional substudy of the Drakenstein Child Health Study. Images from T1-weighted magnetic resonance imaging were acquired on 47 alcohol-exposed and 124 control children (i.e., with no or minimal alcohol exposure), aged 2 to 3 years, some of whom were scanned as neonates. Brain images were processed through automated processing pipelines using FreeSurfer version 6.0. Subcortical and a priori selected cortical regions of interest were compared.

resultsSubcortical volume analyses revealed a PAE by child sex interaction for bilateral putamen volumes (Left: p = 0.02; Right: p = 0.01). There was no PAE by child sex interaction effect on CSA, CV, and CT. Analyses revealed an impact of PAE on CSA (p = 0.04) and CV (p = 0.04), but not CT in this age group. Of note, the inferior parietal gyrus CSA was significantly smaller in children with PAE compared to control children.

conclusionsFindings from this subgroup scanned at age 2 to 3 years build on previously described subcortical volume differences in neonates from this cohort. Findings suggest that PAE persistently affects gray matter development through the critical early years of life. The detectable influence of PAE on brain structure at this early age further highlights the importance of brain imaging studies on the impact of PAE on the young developing brain.

Indexed as

Gray MatterPrenatal Exposure Delayed EffectsAlcohol DrinkingBirth CohortBrainChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfant, NewbornMagnetic Resonance ImagingPregnancySouth Africabrain developmentfetal alcohol spectrum disordersneuroimagingprenatal alcohol exposurestructural MRI

Identifiers

PMID35581528
PMCPMC9357164
OpenAlexW4280623826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.