Evidence map›Paper›PMID 35581508›Full record

ReviewMolecular biology reports2022

Milk fat-globule epidermal growth factor 8: A potential Regulator of Cutaneous Wound Healing.

Yun Xiao, Ying Tang, Xiao Shu, Jinshuo Zhu, Xinan Wu, Yuan Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yun XiaoYunnan Key Laboratory of Stem Cell and Regenerative Medicine & Biomedical Engineering Research Center, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, 650500, Kunming, Yunnan, China.
Ying TangScience and Technology Achievement Incubation Center, Kunming Medical University, Kunming, Yunnan, China.
Xiao ShuThe School of Public Health, Kunming Medical University, Kunming, Yunnan, China.
Jinshuo ZhuYunnan Key Laboratory of Stem Cell and Regenerative Medicine & Biomedical Engineering Research Center, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, 650500, Kunming, Yunnan, China.
Xinan WuThe School of Public Health, Kunming Medical University, Kunming, Yunnan, China.
Yuan ZhangYunnan Key Laboratory of Stem Cell and Regenerative Medicine & Biomedical Engineering Research Center, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, 650500, Kunming, Yunnan, China. zhangyuann@kmmu.edu.cn.ORCID http://orcid.org/0000-0002-5097-7237
Kunming Medical University · CN

Funding

National Natural Science Foundation of China 82060587Yunnan Provincial Science and Technology Department 2018FE001-012Yunnan Provincial Science and Technology Department 2019FF002- 042
6 · The paper itself

Abstract

Destroying the integrity of the skin may causes disability and even death from injury or illness. Wound healing is a core mechanism to maintain skin barrier function. Milk fat-globule epidermal growth factor 8 (MFG-E8) is a key factor in wound healing and is involved in regulating blood coagulation, mediating macrophage uptake of apoptotic cells, shifting macrophages from an inflammatory to an anti-inflammatory phenotype, promoting angiogenesis, enhancing vascular endothelial growth factor (VEGF) signaling, and assisting wound tissue perfusion. However, these abilities are dysregulated in pathological conditions, such as glucose disorders and ischemic injury. Restricted application of exogenous MFG-E8 can restore function and play a beneficial role in cutaneous wound healing.

Indexed as

Antigens, SurfaceMilk ProteinsAnimalsApoptosisEGF Family of ProteinsFactor VIIIMiceMice, Inbred C57BLMilkVascular Endothelial Growth Factor AWound HealingAntigens, SurfaceEGF Family of ProteinsFactor VIIIMilk ProteinsVascular Endothelial Growth Factor AInflammationMFG-E8 accelerates impaired skin wound healing of diabetes and Ischemia/Reperfusion InjuryMFG-E8 is involved in hemostasisProliferation and maturation of wound healing

Identifiers

PMID35581508
OpenAlexW4280496430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.