Evidence map›Paper›PMID 35581390›Full record

Observational studyEuropean journal of pediatrics2022

Role of fluid status markers as risk factors for suboptimal vancomycin concentration during continuous infusion in neonates: an observational study.

V L Cousin, Q Laudouar, N Le Saché, M Mokhtari, P Durand, V Furlan, P Tissières

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Use of Antibiotics in Preterm Newborns.Antibiotics (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

V L CousinPediatric and Neonatology Intensive Care Unit, AP-HP, Bicêtre Hospital, 78, Rue du Général Leclerc, 94275, Le Kremlin-Bicètre, France. vladimir.cousin@hcuge.ch.
Q LaudouarPediatric and Neonatology Intensive Care Unit, AP-HP, Bicêtre Hospital, 78, Rue du Général Leclerc, 94275, Le Kremlin-Bicètre, France.
N Le SachéPediatric and Neonatology Intensive Care Unit, AP-HP, Bicêtre Hospital, 78, Rue du Général Leclerc, 94275, Le Kremlin-Bicètre, France.
M MokhtariPediatric and Neonatology Intensive Care Unit, AP-HP, Bicêtre Hospital, 78, Rue du Général Leclerc, 94275, Le Kremlin-Bicètre, France.
P DurandPediatric and Neonatology Intensive Care Unit, AP-HP, Bicêtre Hospital, 78, Rue du Général Leclerc, 94275, Le Kremlin-Bicètre, France.
V FurlanClinical Pharmacology Laboratory, AP-HP, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
P TissièresPediatric and Neonatology Intensive Care Unit, AP-HP, Bicêtre Hospital, 78, Rue du Général Leclerc, 94275, Le Kremlin-Bicètre, France.
Bicêtre Hospital · FRAssistance Publique – Hôpitaux de Paris · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vancomycin is widely used in neonatal sepsis but proportion of newborn reaching recommended concentration is variable. Fluid status impact on vancomycin level remains understudied. We aimed to study fluid factors impacting vancomycin concentration at 24 h of treatment. We performed a prospective and retrospective observational monocentric study of NICU patients requiring a vancomycin treatment. We used a continuous infusion protocol, with age-appropriate loading and maintenance doses. Vancomycin target serum concentration after 24 h (C

conclusionVancomycin C WHAT IS KNOWN: • Adjustment of vancomycin regimen remains difficult due to inter- and intra-individual variability of vancomycin pharmacokinetics. • Impact of fluid status on vancomycin concentration in critically ill neonates is incompletely studied. WHAT IS NEW: • Proportion of patients with adequate vancomycin concentration using a target adapted to nosocomial gram-positive bacteria MIC is low. • We confirmed the role of creatinine level and report two new factors associated with low vancomycin concentration: presence of systemic inflammation and weight gain.

Indexed as

Neonatal SepsisVancomycinAnti-Bacterial AgentsBiomarkersCreatinineHumansInfantInfant, NewbornProspective StudiesRetrospective StudiesRisk FactorsWeight GainAnti-Bacterial AgentsBiomarkersCreatinineVancomycinFluidNeonatal sepsisPharmacokineticsVancomycin

Identifiers

PMID35581390
OpenAlexW4280536963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.