ArticleScientific reports2022
Brain structural alterations and clinical features of cognitive frailty in Japanese community-dwelling older adults: the Arao study (JPSC-AD).
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Global Prevalence of Cognitive Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026Pooled it
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Cognitive frailty research (2001-2024): a scientometric analysis of its evolution, intellectual structure, and future frontiers.Journal of translational medicine · 2026Review
- Predicting cognitive frailty in older adults: an explainable machine learning model integrating radiomics and clinical features.BMC medical informatics and decision making · 2026Article
- Association between cerebrospinal fluid volume and frailty in community-dwelling older adults: a cross-sectional study.Fluids and barriers of the CNS · 2026Article
- A secondary analysis of cortical atrophy and plasma amyloid β patterns in older patients with cognitive frailty undergoing elective surgery.BMC geriatrics · 2025Article
- A scoring system and seven factors associated with certification for Japanese long-term care insurance in older people.Journal of bone and mineral metabolism · 2025Article
- Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan.GeroScience · 2025Article
- Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study.Frontiers in aging neuroscience · 2025Article
- Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer.Frontiers in aging neuroscience · 2025Article
- Prevalence of cognitive frailty and its associated factors in a population of Iranian older adults.Aging clinical and experimental research · 2024Article
- Gesture imitation performance in community-dwelling older people: assessment of a gesture imitation task in the screening and diagnosis of mild cognitive impairment and dementia.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024Article
- Potential Imaging Biomarkers of Cognitive Frailty.Annals of geriatric medicine and research · 2023Article
- Exploring the relationship between frailty and executive dysfunction: the role of frontal white matter hyperintensities.Frontiers in aging neuroscience · 2023Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive impairment (MCI) and physical frailty (PF). Elderly with CF are at greater risk of dementia than those with MCI or PF alone, but there are few known clinical or neuroimaging features to reliably distinguish CF from PF or MCI. We therefore conducted a population-based cross-sectional study of community elderly combining physical, cognitive, neuropsychiatric, and multisequence magnetic resonance imaging (MRI) evaluations. The MRI evaluation parameters included white matter (WM) lesion volumes, perivascular and deep subcortical WM lesion grades, lacunar infarct prevalence, microbleed number, and regional medial temporal lobe (MTL) volumes. Participants were divided into 4 groups according to the presence or absence of MCI and PF-(1) no MCI, PF (n = 27); (2) no PF, MCI (n = 119); (3) CF (MCI + PF) (n = 21), (4) normal controls (n = 716). Unique features of CF included shorter one-leg standing time; severe depressive symptoms; and MRI signs of significantly more WM lesions, lacunar infarcts, small-vessel disease lesions, microbleeds, and reduced MTL volumes. These unique deficits suggest that interventions for CF prevention and treatment should focus on motor skills, depressive symptoms, and vascular disease risk factor control.
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