Evidence map›Paper›PMID 35581319›Full record

ArticleScientific reports2022

The association between serum glucose to potassium ratio on admission and short-term mortality in ischemic stroke patients.

Yuzhao Lu, Xin Ma, Xiaobing Zhou, Yang Wang

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Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
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30citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yuzhao LuDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Yongwai Zheng Road 17, Nanchang, 330006, China.
Xin MaDepartment of Thoracic Surgery, Jingshan Union Hospital of Huazhong University of Science and Technology, Jingshan, 431899, Hubei, China.
Xiaobing ZhouDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Yongwai Zheng Road 17, Nanchang, 330006, China. Xiaobingzhou1234@163.com.
Yang WangDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Yongwai Zheng Road 17, Nanchang, 330006, China. WangyangNC2021@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High serum glucose to potassium ratio (GPR) at admission is implicated for a poor outcome in acute brain injury, acute intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. However, the relationship between GPR and the outcome of ischemic stroke (IS) remains unknown. In all, 784 IS patients from a large emergency Norwegian cohort were included for secondary analysis. The exposure and outcome were GPR at baseline and all-cause mortality within 30 days after the first admission. Multivariable logistic regression analysis was performed to estimate the risk of 30-day mortality based on GPR levels. In addition, we examined whether there was a nonlinear relationship between admission GPR and 30-day mortality using two-piecewise linear regression with a smoothing function and threshold level analysis. The results of multivariable regression analysis showed that GPR at baseline was positively associated with the 30-day mortality (OR 2.01, 95% CI 1.12, 3.61) after adjusting for potential confounders (age, gender, department, serum sodium, serum albumin, serum-magnesium, hypertension, heart failure, chronic renal failure, and pneumonia). When GPR was translated to a categorical variable, the ORs and 95% CIs in the tertiles 2 to 3 versus the tertile 1 were 1.24 (0.60, 2.56) and 2.15 (1.09, 4.24), respectively (P for trend = 0.0188). Moreover, the results of the two-piecewise linear regression and curve fitting revealed a linear relationship between GPR and 30-day mortality. In IS patients, GPR is positively correlated with 30-day mortality, and the relationship between them is linear. The GPR at admission may be a promising predictor for the short-term outcome in IS patients.

Indexed as

Ischemic StrokeStrokeSubarachnoid HemorrhageGlucoseHumansIntracranial HemorrhagesPotassiumPrognosisRetrospective StudiesGlucosePotassium

Identifiers

PMID35581319
PMCPMC9114007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.