Evidence map›Paper›PMID 35581302›Full record

ArticleScientific reports2022

Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs.

Iman Habibagahi, Mahmoud Omidbeigi, Joseph Hadaya, Hongming Lyu, Jaeeun Jang, Jeffrey L Ardell, Ausaf A Bari, Aydin Babakhani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  8. Miniaturized Wirelessly Powered and Controlled Implants for Multisite Stimulation.IEEE transactions on microwave theory and techniques · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Iman HabibagahiElectrical and Computer Engineering Department, University of California Los Angeles, Los Angeles, CA, USA. ihabibagahi@g.ucla.edu.
Mahmoud OmidbeigiDepartment of Neurosurgery, University of California at Los Angeles, Los Angeles, CA, USA. MOmidbeigi@mednet.ucla.edu.
Joseph HadayaUCLA Cardiac Arrhythmia Center, University of California Los Angeles, Los Angeles, CA, USA.
Hongming LyuElectrical and Computer Engineering Department, University of California Los Angeles, Los Angeles, CA, USA.
Jaeeun JangElectrical and Computer Engineering Department, University of California Los Angeles, Los Angeles, CA, USA.
Jeffrey L ArdellUCLA Cardiac Arrhythmia Center, University of California Los Angeles, Los Angeles, CA, USA.
Ausaf A BariDepartment of Neurosurgery, University of California at Los Angeles, Los Angeles, CA, USA.
Aydin BabakhaniElectrical and Computer Engineering Department, University of California Los Angeles, Los Angeles, CA, USA. aydinbabakhani@ucla.edu.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromodulation of peripheral nerves has been clinically used for a wide range of indications. Wireless and batteryless stimulators offer important capabilities such as no need for reoperation, and extended life compared to their wired counterparts. However, there are challenging trade-offs between the device size and its operating range, which can limit their use. This study aimed to examine the functionality of newly designed wirelessly powered and controlled implants in vagus nerve stimulation for pigs. The implant used near field inductive coupling at 13.56 MHz industrial, scientific, and medical band to harvest power from an external coil. The circular implant had a diameter of 13 mm and weighed 483 mg with cuff electrodes. The efficiency of the inductive link and robustness to distance and misalignment were optimized. As a result, the specific absorption rate was orders of magnitude lower than the safety limit, and the stimulation can be performed using only 0.1 W of external power. For the first time, wireless and batteryless VNS with more than 5 cm operation range was demonstrated in pigs. A total of 84 vagus nerve stimulations (10 s each) have been performed in three adult pigs. In a quantitative comparison of the effectiveness of VNS devices, the efficiency of systems on reducing heart rate was similar in both conventional (75%) and wireless (78.5%) systems. The pulse width and frequency of the stimulation were swept on both systems, and the response for physiological markers was drawn. The results were easily reproducible, and methods used in this study can serve as a basis for future wirelessly powered implants.

Indexed as

Vagus Nerve StimulationWireless TechnologyAnimalsElectrodesPeripheral NervesProstheses and ImplantsSwineVagus Nerve

Identifiers

PMID35581302
PMCPMC9114380
OpenAlexW4280579011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.