Evidence map›Paper›PMID 35581033›Full record

ArticleTrends in genetics : TIG2022

A new Down syndrome rat model races forward.

Randall J Roper, Charles R Goodlett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in genetics : TIG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Randall J RoperDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA. Electronic address: rjroper@iupui.edu.
Charles R GoodlettDepartment of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA; Graduate Program in Addiction Neuroscience, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
University of Indianapolis · US

Funding

Strategies for treatment of Down syndrome: Identifying age- and sex-specific developmental windows using inducible genetic reduction of Dyrk1aR01AR078663 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GOODLETT, CHARLES R., ROPER, RANDALL J · 2020 to 2020
$1.9M
Development and treatment of skeletal deficits in a Down syndrome mouse modelR15HD090603 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI ROPER, RANDALL J · 2017 to 2020
$900k
NIAMS NIH HHS R01 AR078663NICHD NIH HHS R15 HD090603
6 · The paper itself

Abstract

Animal models of Down syndrome (DS) provide an essential resource for understanding genetic, cellular, and molecular contributions to traits associated with trisomy 21 (Ts21). Recent genetic enhancements in the development of DS models, including the new TcHSA21rat model (Kazuki et al.), have potential to transform our understanding of and potential therapies for Ts21.

Indexed as

Down SyndromeAnimalsDisease Models, AnimalPhenotypeRatsanimal modelsgene dosagegene expressionneurodevelopmenttrisomy

Identifiers

PMID35581033
PMCPMC9561036
OpenAlexW4280522823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.