Evidence map›Paper›PMID 35580926›Full record

ArticleJournal for immunotherapy of cancer2022

A

Apple Hui Min Tay, Rubén Prieto-Díaz, Shiyong Neo, Le Tong, Xinsong Chen, Valentina Carannante, Björn Önfelt, Johan Hartman, Felix Haglund, Maria Majellaro and 8 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Applying Deep-Learning-DrivenJournal of medicinal chemistry · 2026
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  15. Adenosine receptors in breast cancer.Molecular biology reports · 2024
    Review
  16. The Immune Regulatory Role of Adenosine in the Tumor Microenvironment.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Apple Hui Min Tay *Department of Biological Science, Nanyang Technological University, Singapore.ORCID 0000-0002-0600-6599
Rubén Prieto-Díaz *Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Shiyong NeoDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Le TongDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Xinsong ChenDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-3214-9075
Valentina CarannanteDepartment of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Björn ÖnfeltDepartment of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Johan HartmanDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Felix HaglundDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Maria MajellaroCenter for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Jhonny AzuajeCenter for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Xerardo Garcia-MeraCenter for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Jose M BreaCenter for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Maria I LozaCenter for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Willem JespersDepartment of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Hugo Gutierrez-de-TeranDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-0459-3491
Eddy SoteloCenter for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain Andreas.Lundqvist@ki.se e.sotelo@usc.es.
Andreas LundqvistDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden Andreas.Lundqvist@ki.se e.sotelo@usc.es.ORCID 0000-0002-9709-2970
Universidade de Santiago de Compostela · ESKarolinska Institutet · SEKarolinska University Hospital · SEScience for Life Laboratory · SEUppsala University · SEAgency for Science, Technology and Research · SGNanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, A

methodsWe report the synthesis and functional evaluation of five potent A

resultsWe provide data for six novel small molecules: five A

conclusionsOur results demonstrate that A

Indexed as

NeoplasmsPurinergic P1 Receptor AntagonistsAdenosineHumansLymphocytesReceptor, Adenosine A2BAdenosinePurinergic P1 Receptor AntagonistsReceptor, Adenosine A2Badenosineimmunotherapylymphocyte activationlymphocytes, tumor-infiltrating

Identifiers

PMID35580926
PMCPMC9115112
OpenAlexW4280580815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.