ArticleNature2022
Structural insights into the HBV receptor and bile acid transporter NTCP.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
15.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Pooled it
- Structural insight into sodium-dependent bile acid transport by members of the SLC10 family.Structure (London, England : 1993) · 2026Article
- Review
- HBV Envelope Protein-Bearing Vesicles Show Preferential Uptake in Hepatocyte-Derived Cells.International journal of molecular sciences · 2026Article
- Post-Translational Modifications of NTCP: A Regulatory Nexus for Bile Acid Transport and HBV Entry.Biomedicines · 2026Review
- mRNA vaccines for HBV: Mechanisms, preclinical advances, and therapeutic clinical progress.Molecular therapy. Nucleic acids · 2026Review
- HBV reprograms the tumor microenvironment in hepatocellular carcinoma: mechanisms and therapeutic implications.Clinical and experimental medicine · 2026Review
- Multistep receptor binding of the hepatitis B virus preS1 domain.Nature communications · 2026Article
- Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter.PLoS pathogens · 2026Article
- Emerging antiviral drugs and immunotherapy for chronic hepatitis B and associated liver disease.Frontiers in immunology · 2026Review
- NTCP ubiquitination enables HBV infection.JHEP reports : innovation in hepatology · 2025Article
- Amino acid substitutions at rheostat positions in the NaProtein science : a publication of the Protein Society · 2025Article
- The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.Physiological reviews · 2025Review
- Interaction between W41 of the hepatitis B virus preS1 surface peptide and Y146/F274 of the cellular receptor molecule NaMolecular pharmacology · 2025Article
- Characterization of genetic mutations in hepatitis B virus isolated from HBsAg+/HBcAb+/HBsAb-/HBV DNA + Japanese blood donors.Scientific reports · 2025Article
- Emerging therapies for HBsAg seroclearance: spotlight on novel combination strategies.Hepatology international · 2025Review
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- Recent Advances in mRNA-Based Vaccines Against Several Hepatitis Viruses.Biological procedures online · 2025Review
- [Research progress on new drugs for the treatment of chronic hepatitis B virus infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
- Hepatitis B and D virus entry.Nature reviews. Microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 7 institutions in 3 countries.
Jae-Hyun ParkDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID http://orcid.org/0000-0001-5690-9705
Masashi IwamotoDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Ji-Hye YunDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.
Tomomi Uchikubo-KamoLaboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Donghwan SonDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-0811-4972
Zeyu JinDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID http://orcid.org/0000-0002-6478-2967
Hisashi YoshidaDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Mio OhkiDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Naito IshimotoDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Kenji MizutaniDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Mizuki OshimaDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Masamichi MuramatsuDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Takaji WakitaDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Mikako ShirouzuLaboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.ORCID http://orcid.org/0000-0002-7997-2149
Kehong LiuDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tomoko UemuraDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Norimichi NomuraDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-6330-2239
So IwataDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-1735-2937
Koichi WatashiDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Jeremy R H TameDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID http://orcid.org/0000-0002-9341-7280
Tomohiro NishizawaLaboratory of Biomembrane Dynamics, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID http://orcid.org/0000-0001-7463-8398
Weontae LeeDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea. wlee@spin.yonsei.ac.kr.
Sam-Yong ParkDrug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan. park@yokohama-cu.ac.jp.ORCID http://orcid.org/0000-0001-6164-8896
Yokohama City University · JPKyoto University · JPYonsei University · KRNational Institute of Infectious Diseases · JPRIKEN Center for Biosystems Dynamics Research · JPTokyo University of Science · JPYokohama City University Medical Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Around 250 million people are infected with hepatitis B virus (HBV) worldwide
Indexed as
Bile Acids and SaltsCryoelectron MicroscopyHepatitis B virusOrganic Anion Transporters, Sodium-DependentReceptors, VirusSymportersAntibodiesHepatocytesHumansAntibodiesBile Acids and SaltsOrganic Anion Transporters, Sodium-DependentReceptors, Virussodium-bile acid cotransporterSymporters
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.