Evidence map›Paper›PMID 35580341›Full record

ArticleACS biomaterials science & engineering2022

Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing.

Sara E Maloney, Christopher A Broberg, Quincy E Grayton, Samantha L Picciotti, Hannah R Hall, Shannon M Wallet, Robert Maile, Mark H Schoenfisch

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Spatiotemporal NO/OTheranostics · 2026
    Article
  4. Article
  5. Review
  6. Biopolymeric Inhalable Dry Powders for Pulmonary Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sara E MaloneyDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Christopher A BrobergDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Quincy E GraytonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Samantha L PicciottiDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Hannah R HallDepartment of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Shannon M WalletDivision of Oral, Craniofacial, and Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Robert MaileDepartment of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Mark H SchoenfischDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-2212-0658
University of North Carolina at Chapel Hill · US

Funding

Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensorsR01DK108318 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHOENFISCH, MARK H · 2016 to 2023
$4.5M
Nitric oxide-releasing dendrimers for the treatment of periodontal diseaseR01DE025207 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHOENFISCH, MARK H · 2015 to 2019
$1.6M
NIDCR NIH HHS R01 DE025207NIDDK NIH HHS R01 DK108318
6 · The paper itself

Abstract

Two glycosaminoglycan (GAG) biopolymers, hyaluronic acid (HA) and chondroitin sulfate (CS), were chemically modified via carbodiimide chemistry to facilitate the loading and release of nitric oxide (NO) to develop a multi-action wound healing agent. The resulting NO-releasing GAGs released 0.2-0.9 μmol NO mg

Indexed as

GlycosaminoglycansNitric OxideAnimalsFibroblastsHumansHyaluronic AcidMiceWound HealingGlycosaminoglycansHyaluronic AcidNitric Oxideantibacterialchondroitin sulfatehyaluronic acidnitric oxidewound healing

Identifiers

PMID35580341
PMCPMC11574979
OpenAlexW4280587186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.