Evidence map›Paper›PMID 35580164›Full record

ReviewAmerican journal of respiratory cell and molecular biology2022

New Insights Relating Gasdermin B to the Onset of Childhood Asthma.

Nathan Schoettler, Eishika Dissanayake, Mark W Craven, Jeremiah S Yee, Joshua Eliason, Eric M Schauberger, Robert F Lemanske, Carole Ober, James E Gern

Open access · greenAbstract readReview
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025
    Pooled it
  2. The ubiquitin ligase FBXW7 regulates epithelial pyroptosis in severe asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  3. Article
  4. Genetic Susceptibility to Acute Viral Bronchiolitis.The Journal of infectious diseases · 2025
    Article
  5. Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  6. Independent association of a 17q21 variant with exacerbations in type 2-low adult asthma.The journal of allergy and clinical immunology. Global · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Farm animal exposure, respiratory illnesses, and nasal cell gene expression.The Journal of allergy and clinical immunology · 2024
    Article
  12. Novel Role of the GSDMB/IFNG Axis in Childhood Asthma.American journal of respiratory and critical care medicine · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nathan SchoettlerDepartment of Medicine and.
Eishika DissanayakeDepartment of Pediatrics and.
Mark W CravenDepartment of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Jeremiah S YeeDepartment of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Joshua EliasonDepartment of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Eric M SchaubergerDepartment of Pediatrics and.
Robert F LemanskeDepartment of Pediatrics and.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, Illinois; and.
James E GernDepartment of Pediatrics and.ORCID 0000-0002-6667-4708
University of Wisconsin–Madison · USUniversity of Chicago · US

Funding

Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUG3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2016 to 2024
$19.3M
Genetics of Asthma Sub-Phenotypes Impact Gene Regulation in Cell-Specific PatternsK08HL153955 · NHLBI · UNIVERSITY OF CHICAGO · PI SCHOETTLER, NATHAN R · 2020 to 2024
$785k
NHLBI NIH HHS K08 HL153955NHLBI NIH HHS L30 HL154452NIH HHS T15 LM007359NIH HHS UG3 OD023282NIH HHS UH3 OD023282NLM NIH HHS T15 LM007359ODCDC CDC HHS UG3 OD023282
6 · The paper itself

Abstract

Chromosome 17q12-q21 is the most replicated genetic locus for childhood-onset asthma. Polymorphisms in this locus containing ∼10 genes interact with a variety of environmental exposures in the home and outdoors to modify asthma risk. However, the functional basis for these associations and their linkages to the environment have remained enigmatic. Within this extended region, regulation of

Indexed as

AsthmaGenome-Wide Association StudyGasderminsGenetic LociGenetic Predisposition to DiseaseHumansNeoplasm ProteinsPolymorphism, Single NucleotidePore Forming Cytotoxic ProteinsGasderminsGSDMB protein, humanNeoplasm ProteinsPore Forming Cytotoxic Proteins17q12-q21asthmagene-by-environment interactionGSDMBpyroptosis

Identifiers

PMID35580164
PMCPMC9564923
OpenAlexW4280595436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.