Evidence map›Paper›PMID 35579916›Full record

ArticleEmerging microbes & infections2022

Recombinant adeno-associated virus serotype 9 AAV-RABVG expressing a Rabies Virus G protein confers long-lasting immune responses in mice and non-human primates.

Chenjuan Shi, Li Tian, Wenwen Zheng, Yelei Zhu, Peilu Sun, Lele Liu, Wenkai Liu, Yanyan Song, Xianzhu Xia, Xianghong Xue and 1 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chenjuan ShiDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Li TianDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Wenwen ZhengDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Yelei ZhuDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Peilu SunInstitute of Materia Medical, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Lele LiuDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Wenkai LiuDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Yanyan SongDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Xianzhu XiaInstitute of Military Veterinary Medicine, Academy of Military Medical Science, Changchun, People's Republic of China.
Xianghong XueDivisions of Infectious Diseases of Special Animal, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, People's Republic of China.
Xuexing ZhengDepartment of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Shandong University · CNAcademy of Military Medical Sciences · CNChinese Academy of Agricultural Sciences · CNMateria (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three or four intramuscular doses of the inactivated human rabies virus vaccines are needed for pre- or post-exposure prophylaxis in humans. This procedure has made a great contribution to prevent human rabies deaths, which bring huge economic burdens in developing countries. Herein, a recombinant adeno-associated virus serotype 9, AAV9-RABVG, harbouring a RABV G gene, was generated to serve as a single dose rabies vaccine candidate. The RABV G protein was stably expressed in the 293T cells infected with AAV9-RABVG. A single dose of 2 × 10

Indexed as

RabiesRabies VaccinesRabies virusAnimalsAntibodies, ViralDependovirusGTP-Binding ProteinsImmunity, CellularInterleukin-4MiceMice, Inbred BALB CPrimatesSerogroupAntibodies, ViralGTP-Binding ProteinsInterleukin-4Rabies VaccinesAdeno-associated virus serotype 9glycoproteinneutralizing antibodiesrabies virusvaccine

Identifiers

PMID35579916
PMCPMC9154782
OpenAlexW4280513364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.