ArticleApplied biochemistry and biotechnology2022
Promising Endophytic Alternaria alternata from Leaves of Ziziphus spina-christi: Phytochemical Analyses, Antimicrobial and Antioxidant Activities.
Article in Applied biochemistry and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Computational screening of Alternaria metabolites as potential DPP-4 inhibitors: ADMET, molecular docking, molecular dynamics, and network pharmacology analysis.Molecular diversity · 2026Article
- Untapped microbial factories for next-generation therapeutics: Endophytic fungi of medicinal plants.Microbial cell factories · 2026Review
- Innovative fungal bioagents: producing siderophores, IAA, and HCN to support plants under salinity stress and combat microbial plant pathogens.Microbial cell factories · 2025Article
- Phytochemical profiling and evaluation of antioxidant, anticancer, antimicrobial and antibiofilm activities of endophytic fungi isolated from Lavandula stricta.Scientific reports · 2025Article
- Antimicrobial, antibiofilm and antioxidant activities of bioactive secondary metabolites of marine Scarus ghobban gut-associated Aspergillus niger: In-vitro and in-silico studies.Scientific reports · 2025Article
- In Vitro Antioxidant and Antibacterial Activities of Ethyl Acetate Extracts ofMicroorganisms · 2024Article
- Anti-inflammatory potential of aconitine produced by endophytic fungus Acremonium alternatum.World journal of microbiology & biotechnology · 2024Article
- Profile andHeliyon · 2024Article
- Investigation the biological activities and the metabolite profiles of endophytic fungi isolated from Gundelia tournefortii L.Scientific reports · 2024Article
- Revealing culturable fungal microbiome communities from the Arabian Peninsula desert representing a unique source of biochemicals for drug discovery and biotechnology.F1000Research · 2024Article
- Antibacterial and anticancer potential of bioactive compounds and secondary metabolites of endophytic fungi isolated fromFrontiers in microbiology · 2024Article
- Antimicrobial, antiproliferative activities and molecular docking of metabolites from Alternaria alternata.AMB Express · 2023Article
- Bioactive compounds and biomedical applications of endophytic fungi: a recent review.Microbial cell factories · 2023Review
- Isolation and identification of novel selective antitumor constituents, sidrin and sidroside, fromSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Biostimulation of tomato growth and biocontrol of Fusarium wilt disease using certain endophytic fungi.Botanical studies · 2022Article
- Secondary metabolites produced by endophytic fungi,Frontiers in genetics · 2022Article
- Cultivable endophytic fungal community associated with the karst endemic plantFrontiers in microbiology · 2022Article
- The effects ofClinical pathology (Thousand Oaks, Ventura County, Calif.)Article
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4 authors.
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Abstract
Fungal endophytes are considered one of the most important reservoirs of bioactive compounds which defeat resistant microbes. In our study, endophytic Alternaria alternata was isolated from Ziziphus spina-christi and identified morphologically and genetically with accession number OM 331,682. Preliminary phytochemical screening of ethyl acetate (EA) crude extract of A. alternata revealed that this extract contains alkaloids, tannins, flavonoids, glycosides, phenols, and terpenoids. Moreover, the extract was analyzed using gas chromatography-mass spectrometry (GC-MS) which verified the presence of numerous bioactive compounds. Antimicrobial results illustrated that EA crude extract exhibited promising antimicrobial activity against Gram-negative bacteria (Escherichia coli ATCC 11229, Proteus vulgaris RCMB 004, Pseudomonas aeruginosa ATCC 27853, and Klebsiella pneumonia RCMB 003), Gram-positive bacteria (Bacillus subtilis RCMB 015, Staphylococcus aureus ATCC 25923, and Staphylococcus epidermidis ATCC 14990), and unicellular fungi (Candida albicans ATCC 90028). Ultrastructure study of treated K. pneumonia showed remarkably elucidated destruction of the cell wall and cell membrane and leakage of cytoplasmic materials. Furthermore, the extract has potential antioxidant activity where IC
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