ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022
Multidimensional frailty and quality of life: data from the English Longitudinal Study of Ageing.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06767410 (A Multi-domain Intervention to Constrast Cognitive Decline in Healthy Aging), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-domain Intervention to Constrast Cognitive Decline in Healthy Aging
Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Mapping longitudinal evidence on multidimensional frailty among community-dwelling older adults: protocol for a scoping review.BMJ open · 2026Article
- Prevalence of pre-frailty and frailty and their association with postoperative hospital days in older adults referred for elective orthopaedic surgery.European geriatric medicine · 2026Article
- Cost effectiveness of comprehensive geriatric assessment: a systematic review.Health economics review · 2026Review
- Frailty and quality of life in older ICU survivors: a scoping review of assessment tools and methodologies.BMC geriatrics · 2026Article
- Parkinson's Disease and Frailty: A Two-Way Link Across Aging.Journal of clinical medicine · 2025Review
- Multicomponent prehabilitation and perioperative care in older persons with frailty referred to planned orthopaedic surgery: A feasibility study.Aging clinical and experimental research · 2025Article
- Frailty, multimorbidity and quality of life in an ageing population in Africa: a cross-sectional, population-based study in rural and urban Rwanda.Family medicine and community health · 2025Article
- The effect of community health nurse-led multi-faceted group-based frailty prevention program for older adults: a multi-site pretest-posttest design.BMC nursing · 2025Article
- Usefulness of a new digital version of the MPI-SVaMA (MPI-SVaMA Digit) in predicting short- and long-term mortality in community-dwelling older people.Aging clinical and experimental research · 2025Article
- Association between multidimensional frailty and quality of life in older adults with coronary heart disease: a cross-sectional study.Frontiers in psychology · 2025Article
- Bidirectional association between frailty and quality of life within English longitudinal study of aging.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Frailty and nutritional inadequacy in older Korean adults: A gender-stratified analysis using National Survey Data.PloS one · 2025Article
- Article
- Thanks for hearing me: key elements of primary care according to older patients.Scandinavian journal of primary health care · 2024Article
- A Biopsychosocial Model Predicting Myocardial Infarction.Journal of clinical medicine · 2023Article
- Can the Multidimensional Prognostic Index (MPI) be a predictive instrument for mortality in older adult liver transplant candidates?European geriatric medicine · 2023Observational
- The Longitudinal Association Between Frailty, Cognition, and Quality of Life in Older Europeans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Frailty among inpatients with Schizophrenia: Status, influencing factors, and their correlation with quality of life.Frontiers in psychiatry · 2022Article
- Frailty Viewed From a Nursing Perspective.SAGE open nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFrailty has been found to be associated with poor quality of life (QoL) in older people, but data available are limited to cross-sectional studies. We therefore aimed to assess the association between multidimensional frailty, determined by Multidimensional Prognostic Index (MPI), with mortality and good QoL expectancy (GQoLE) in a large representative sample of older adults, over 10 years of follow-up.
methodsIn the English Longitudinal Study of Ageing, using the data from 2004-2005 and 2014-2015, MPI was calculated using a weighted score of domains of comprehensive geriatric assessment, i.e., number of difficulties in activities of daily living (ADL) and instrumental ADL, depressive symptoms, number of medical conditions, body mass index, physical activity level, and social aspects. Mortality was assessed using administrative data, GQoLE indicators were used for longitudinal changes in QoL.
results6244 Participants (mean age 71.8 years, 44.5% males) were followed up for 10 years. After adjusting for potential confounders, compared to people in the MPI low-risk group, people in the moderate (hazard ratio, HR = 4.27; 95% confidence interval, CI 3.55-5.14) and severe-risk group (HR = 10.3; 95% CI 7.88-13.5) experienced a significantly higher mortality rate. During the follow-up period, people in the moderate and severe-risk groups reported lower GQoLE values than their counterparts, independently from age and gender.
conclusionsMultidimensional frailty was associated with a higher risk of mortality and significantly lower GQoLE, suggesting that the multifactorial nature of frailty is associated not only with mortality, but also poor QoL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.