Evidence map›Paper›PMID 35579560›Full record

ArticleEuropean journal of immunology2022

Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using nonredundant immune mechanisms in mice.

Jelka Pohar, Richard O'Connor, Benoît Manfroi, Mohamed El-Behi, Luc Jouneau, Pierre Boudinot, Mario Bunse, Wolfgang Uckert, Marine Luka, Mickael Ménager and 3 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Jelka PoharInstitut Necker Enfants Malades, Institut National de la Santé et de la Recherche Médicale INSERM U1151 - Centre National de la Recherche Scientifique CNRS UMR 8253, Paris, France.ORCID 0000-0002-7616-164X
Richard O'ConnorUniversity of Edinburgh, Edinburgh, UK.
Benoît ManfroiInstitut Necker Enfants Malades, Institut National de la Santé et de la Recherche Médicale INSERM U1151 - Centre National de la Recherche Scientifique CNRS UMR 8253, Paris, France.
Mohamed El-BehiInstitut Necker Enfants Malades, Institut National de la Santé et de la Recherche Médicale INSERM U1151 - Centre National de la Recherche Scientifique CNRS UMR 8253, Paris, France.
Luc JouneauUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Pierre BoudinotUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Mario BunseMax Delbrück Center for Molecular Medicine, The Helmholtz Association, Berlin, Germany.
Wolfgang UckertMax Delbrück Center for Molecular Medicine, The Helmholtz Association, Berlin, Germany.
Marine LukaLaboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, Université de Paris, Imagine Institute, Paris, France.
Mickael MénagerLaboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, Université de Paris, Imagine Institute, Paris, France.
Roland LiblauInfinity-Institut Toulousain des Maladies Infectieuses et Inflammatoires, Université Toulouse III, Toulouse, France.
Stephen M AndertonUniversity of Edinburgh, Edinburgh, UK.
Simon FillatreauInstitut Necker Enfants Malades, Institut National de la Santé et de la Recherche Médicale INSERM U1151 - Centre National de la Recherche Scientifique CNRS UMR 8253, Paris, France.ORCID 0000-0002-7730-9917
Centre National de la Recherche Scientifique · FRMax Delbrück Center · DEUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris Cité · FRUniversity of Edinburgh · GBHôpital Necker-Enfants Malades · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD4

Indexed as

AutoimmunityImmune System DiseasesAnimalsCell- and Tissue-Based TherapyCTLA-4 AntigenForkhead Transcription FactorsInterleukin-10MiceReceptors, AntigenT-Lymphocytes, RegulatoryCTLA-4 AntigenForkhead Transcription FactorsInterleukin-10Receptors, AntigenAutoimmunityCell therapyFOXP3Gene therapyRegulatory T cells

Identifiers

PMID35579560
PMCPMC9542066
OpenAlexW4280536432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.