Evidence map›Paper›PMID 35579522›Full record

ReviewRadiology2022

Radiomic Analysis: Study Design, Statistical Analysis, and Other Bias Mitigation Strategies.

Chaya S Moskowitz, Mattea L Welch, Michael A Jacobs, Brenda F Kurland, Amber L Simpson

Open access · greenAbstract readReview
In one paragraph

Review in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Development and validation of a prognostic prediction model for lumbar-disc herniation based on machine learning and fusion of clinical text data and radiomic features.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Reproducibility and interpretability in radiomics: a critical assessmentDiagnostic and interventional radiology (Ankara, Turkey) · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chaya S Moskowitz *From the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Ave, 2nd Floor, New York, NY, NY 10017 (C.S.M.); Cancer Digital Intelligence Program, University Health Network, Toronto, ON, Canada (M.L.W.); The Russell H. Morgan Department of Radiology and Radiological Science and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (M.A.J.); ERT, Pittsburgh, Pa (B.F.K.); and School of Computing, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada (A.L.S.).ORCID 0000-0002-2850-8450
Mattea L Welch *From the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Ave, 2nd Floor, New York, NY, NY 10017 (C.S.M.); Cancer Digital Intelligence Program, University Health Network, Toronto, ON, Canada (M.L.W.); The Russell H. Morgan Department of Radiology and Radiological Science and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (M.A.J.); ERT, Pittsburgh, Pa (B.F.K.); and School of Computing, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada (A.L.S.).ORCID 0000-0002-5887-9826
Michael A JacobsFrom the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Ave, 2nd Floor, New York, NY, NY 10017 (C.S.M.); Cancer Digital Intelligence Program, University Health Network, Toronto, ON, Canada (M.L.W.); The Russell H. Morgan Department of Radiology and Radiological Science and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (M.A.J.); ERT, Pittsburgh, Pa (B.F.K.); and School of Computing, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada (A.L.S.).ORCID 0000-0002-1125-1644
Brenda F KurlandFrom the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Ave, 2nd Floor, New York, NY, NY 10017 (C.S.M.); Cancer Digital Intelligence Program, University Health Network, Toronto, ON, Canada (M.L.W.); The Russell H. Morgan Department of Radiology and Radiological Science and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (M.A.J.); ERT, Pittsburgh, Pa (B.F.K.); and School of Computing, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada (A.L.S.).ORCID 0000-0002-5669-0595
Amber L SimpsonFrom the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Ave, 2nd Floor, New York, NY, NY 10017 (C.S.M.); Cancer Digital Intelligence Program, University Health Network, Toronto, ON, Canada (M.L.W.); The Russell H. Morgan Department of Radiology and Radiological Science and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (M.A.J.); ERT, Pittsburgh, Pa (B.F.K.); and School of Computing, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada (A.L.S.).ORCID 0000-0002-4387-8417
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Multi-Modality Quantitiative Imaging for Evaluation of Response to Cancer TherapyU01CA140204 · NCI · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, SOLNES, LILJA · 2011 to 2022
$6.1M
Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver MetastasesR01CA233888 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHUN, YUN SHIN, DO, RICHARD KINH GIAN · 2019 to 2023
$3.7M
NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA233888NCI NIH HHS U01 CA140204
6 · The paper itself

Abstract

Rapid advances in automated methods for extracting large numbers of quantitative features from medical images have led to tremendous growth of publications reporting on radiomic analyses. Translation of these research studies into clinical practice can be hindered by biases introduced during the design, analysis, or reporting of the studies. Herein, the authors review biases, sources of variability, and pitfalls that frequently arise in radiomic research, with an emphasis on study design and statistical analysis considerations. Drawing on existing work in the statistical, radiologic, and machine learning literature, approaches for avoiding these pitfalls are described.

Indexed as

Machine LearningRadiologyBiasHumansResearch Design

Identifiers

PMID35579522
PMCPMC9340236
OpenAlexW4280601680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.