Evidence map›Paper›PMID 35579521›Full record

ArticleRadiology2022

Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum.

Jong Duck Choi, Yeonsil Moon, Hee-Jin Kim, Younghee Yim, Subin Lee, Won-Jin Moon

Abstract read
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In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Chronic kidney disease and cognitive decline: choroid plexus remodeling, glymphatic dysfunction, and alzheimer biomarker interpretation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  6. Article
  7. Choroid Plexus Abnormalities in Autoimmune Encephalitis.CNS neuroscience & therapeutics · 2026
    Article
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  9. Regional differences inAnnals of nuclear medicine · 2026
    Article
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  11. Article
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  17. Observational
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  19. Choroid plexus remodeling linked to impaired CSF-mediated clearance and Alzheimer's disease progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  20. Article

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jong Duck ChoiFrom the Departments of Radiology (J.D.C., W.J.M.) and Neurology (Y.M.), Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea (Y.M., W.J.M.); Department of Neurology, Hanyang University Hospital, Hanyang University School of Medicine, Seoul, Korea (H.J.K.); Department of Radiology, Chung-Ang University Hospital, Chung-Ang University School of Medicine, Seoul, Korea (Y.Y.); and Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea (S.L.).ORCID 0000-0003-3566-2568
Yeonsil MoonFrom the Departments of Radiology (J.D.C., W.J.M.) and Neurology (Y.M.), Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea (Y.M., W.J.M.); Department of Neurology, Hanyang University Hospital, Hanyang University School of Medicine, Seoul, Korea (H.J.K.); Department of Radiology, Chung-Ang University Hospital, Chung-Ang University School of Medicine, Seoul, Korea (Y.Y.); and Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea (S.L.).
Hee-Jin KimFrom the Departments of Radiology (J.D.C., W.J.M.) and Neurology (Y.M.), Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea (Y.M., W.J.M.); Department of Neurology, Hanyang University Hospital, Hanyang University School of Medicine, Seoul, Korea (H.J.K.); Department of Radiology, Chung-Ang University Hospital, Chung-Ang University School of Medicine, Seoul, Korea (Y.Y.); and Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea (S.L.).
Younghee YimFrom the Departments of Radiology (J.D.C., W.J.M.) and Neurology (Y.M.), Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea (Y.M., W.J.M.); Department of Neurology, Hanyang University Hospital, Hanyang University School of Medicine, Seoul, Korea (H.J.K.); Department of Radiology, Chung-Ang University Hospital, Chung-Ang University School of Medicine, Seoul, Korea (Y.Y.); and Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea (S.L.).ORCID 0000-0002-4224-7832
Subin LeeFrom the Departments of Radiology (J.D.C., W.J.M.) and Neurology (Y.M.), Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea (Y.M., W.J.M.); Department of Neurology, Hanyang University Hospital, Hanyang University School of Medicine, Seoul, Korea (H.J.K.); Department of Radiology, Chung-Ang University Hospital, Chung-Ang University School of Medicine, Seoul, Korea (Y.Y.); and Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea (S.L.).ORCID 0000-0001-7583-6468
Won-Jin MoonFrom the Departments of Radiology (J.D.C., W.J.M.) and Neurology (Y.M.), Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea (Y.M., W.J.M.); Department of Neurology, Hanyang University Hospital, Hanyang University School of Medicine, Seoul, Korea (H.J.K.); Department of Radiology, Chung-Ang University Hospital, Chung-Ang University School of Medicine, Seoul, Korea (Y.Y.); and Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea (S.L.).ORCID 0000-0002-8925-7376

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Mounting evidence suggests that the choroid plexus (CP) plays an important role in the pathophysiology of Alzheimer disease (AD), but its imaging profile in cognitive impairment remains unclear. Purpose To evaluate CP volume, permeability, and susceptibility by using MRI in patients at various stages of cognitive impairment. Materials and Methods This retrospective study evaluated patients with cognitive symptoms who underwent 3.0-T MRI of the brain, including dynamic contrast-enhanced (DCE) imaging and quantitative susceptibility mapping (QSM), between January 2013 and May 2020. CP volume was automatically segmented using three-dimensional T1-weighted sequences; the volume transfer constant (ie,

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedBrainChoroid PlexusFemaleHumansMagnetic Resonance ImagingPermeabilityRetrospective Studies

Identifiers

PMID35579521

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.