Evidence map›Paper›PMID 35579475›Full record

ArticleMicrobiology spectrum2022

Prophylactic Delivery of a Bacteriophage Cocktail in Feed Significantly Reduces Salmonella Colonization in Pigs.

Anisha M Thanki, Guillaume Mignard, Robert J Atterbury, Paul Barrow, Andrew D Millard, Martha R J Clokie

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 47 citations in OpenAlex.

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  15. Isolation of phages infecting the zoonotic pathogenbioRxiv : the preprint server for biology · 2025
    Article
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  17. The potential of using bacteriophages targetingFrontiers in microbiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Anisha M ThankiDepartment of Genetics and Genome Biology, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Guillaume MignardDepartment of Genetics and Genome Biology, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Robert J AtterburySchool of Veterinary Medicine and Science, University of Nottinghamgrid.4563.4, Sutton Bonington, Leicestershire, United Kingdom.ORCID 0000-0002-9698-7748
Paul BarrowSchool of Veterinary Medicine, University of Surrey, Daphne Jackson Road, Guildford, United Kingdom.
Andrew D MillardDepartment of Genetics and Genome Biology, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Martha R J ClokieDepartment of Genetics and Genome Biology, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
University of Leicester · GBUniversity of Nottingham · GBUniversity of Surrey · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P005128/1
6 · The paper itself

Abstract

Nontyphoidal Salmonella spp. are a leading cause of human food poisoning and can be transmitted to humans via consuming contaminated pork. To reduce Salmonella spread to the human food chain, bacteriophage (phage) therapy could be used to reduce bacteria from animals' preslaughter. We aimed to determine if adding a two-phage cocktail to feed reduces Salmonella colonization in piglets. This first required spray drying phages to allow them to be added as a powder to feed, and phages were spray dried in different excipients to establish maximum recovery. Although laboratory phage yields were not maintained during scale up in a commercial spray dryer (titers fell from 3 × 10

Indexed as

BacteriophagesFoodborne DiseasesSalmonella PhagesAnimalsRNA, Ribosomal, 16SSalmonellaSwineRNA, Ribosomal, 16Sbacteriophagesbacteriophage therapyfood-borne pathogensSalmonella

Identifiers

PMID35579475
PMCPMC9241700
OpenAlexW4280578584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.