ArticlePlant physiology2022
Selenium-binding Protein 1 (SBD1): A stress response regulator in Chlamydomonas reinhardtii.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Uridine diphosphate glucose confers oxidative stress tolerance in microalgae.BMC plant biology · 2025Article
- Selenium-Binding Protein 1-Deficient Dendritic Cells Protect Mice from Sepsis by Increased Treg/Th17.Antioxidants (Basel, Switzerland) · 2025Article
- Global omics study of Tetraselmis chuii reveals time-related metabolic adaptations upon oxidative stress.Applied microbiology and biotechnology · 2024Article
- Omics exploration of Tetraselmis chuii adaptations to diverse light regimes.Antonie van Leeuwenhoek · 2024Article
- Selenium-Binding Protein 1 (SBP1): A New Putative Player of Stress Sensing in Plants.International journal of molecular sciences · 2024Review
- Generating Mutant for a Stress-Responsive Gene in Rice Using CRISPR-Cas9 System.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Evolutionary Aspects of Selenium Binding Protein (SBP).Journal of molecular evolution · 2023Article
- The SAH7 Homologue of the Allergen Ole e 1 Interacts with the Putative Stress Sensor SBP1 (Selenium-Binding Protein 1) inInternational journal of molecular sciences · 2023Article
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Authors and funding
7 authors.
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Abstract
Selenium-binding proteins (SBPs) represent a ubiquitous protein family implicated in various environmental stress responses, although the exact molecular and physiological role of the SBP family remains elusive. In this work, we report the identification and characterization of CrSBD1, an SBP homolog from the model microalgae Chlamydomonas reinhardtii. Growth analysis of the C. reinhardtii sbd1 mutant strain revealed that the absence of a functional CrSBD1 resulted in increased growth under mild oxidative stress conditions, although cell viability rapidly declined at higher hydrogen peroxide (H2O2) concentrations. Furthermore, a combined global transcriptomic and metabolomic analysis indicated that the sbd1 mutant exhibited a dramatic quenching of the molecular and biochemical responses upon H2O2-induced oxidative stress when compared to the wild-type. Our results indicate that CrSBD1 represents a cell regulator, which is involved in the modulation of C. reinhardtii early responses to oxidative stress. We assert that CrSBD1 acts as a member of an extensive and conserved protein-protein interaction network including Fructose-bisphosphate aldolase 3, Cysteine endopeptidase 2, and Glutaredoxin 6 proteins, as indicated by yeast two-hybrid assays.
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