Evidence map›Paper›PMID 35579357›Full record

ArticleInteractive cardiovascular and thoracic surgery2022

How can the rate of nontherapeutic thymectomy be reduced?

Shuai Wang, Yongqiang Ao, Jiahao Jiang, Miao Lin, Gang Chen, Junzhen Liu, Shihai Zhao, Jian Gao, Yi Zhang, Jianyong Ding and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interactive cardiovascular and thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Shuai WangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yongqiang AoDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiahao JiangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Miao LinDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Gang ChenDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Junzhen LiuDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shihai ZhaoDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jian GaoDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yi ZhangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jianyong DingDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Lijie TanDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Fudan University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNZhongshan Hospital · CNSun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81972168Research Development Fund of Zhongshan Hospital, Fudan University 2020ZSCX11
6 · The paper itself

Abstract

objectivesThe aim of this study was to determine the prevalence of nontherapeutic thymectomy and define a clinical standard to reduce it.

methodsFrom 2016 to 2020, consecutive patients who underwent thymectomy were retrospectively reviewed. Univariable and multivariable analyses were used to identify the correlation factors of nontherapeutic thymectomy. A receiver operating characteristic curve was analysed to assess the cut-off threshold of factors correlated with nontherapeutic thymectomy.

resultsA total of 1039 patients were included in this study. Overall, 78.4% (n = 814) of thymectomies were therapeutic and 21.6% (n = 225) were nontherapeutic. Thymoma (57.9%, n = 602) was the most common diagnosis in therapeutic thymectomy. Among those of nontherapeutic thymectomy, thymic cysts (11.9%, n = 124) were the most common lesion. Compared with therapeutic thymectomy, patients with nontherapeutic thymectomy were more likely to be younger (median age 50.1 vs 55.6 years, P < 0.001) with a smaller precontrast and postcontrast computed tomography (CT) value (P < 0.001, P < 0.001), as well as ΔCT value [10.7 vs 23.5 Hounsfield units (HU), P < 0.001]. Multivariable analysis indicated that only age and ΔCT value were significantly different between therapeutic and nontherapeutic thymectomy groups. Receiver operating characteristic curve analysis showed that cut-off values of age and ΔCT value were 44 years and 6 HU, respectively. Patients with age ≤44 years and a ΔCT value ≤6 HU had a 95% probability of nontherapeutic thymectomy.

conclusionsSurgeons should be cautious to perform thymectomy for patients with age ≤44 years and ΔCT value ≤6 HU. This simple clinical standard is helpful to reduce the rate of nontherapeutic thymectomy.

Indexed as

Mediastinal CystThymomaThymus NeoplasmsAdultHumansMiddle AgedRetrospective StudiesThymectomyCT attenuationLymphomaNontherapeutic thymectomyThymic cystThymoma

Identifiers

PMID35579357
PMCPMC9419679
OpenAlexW4280569654

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