Evidence map›Paper›PMID 35579185›Full record

SynthesisThe Journal of international medical research2022

MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis.

Guping Zhong, Xiaojin Luo, Ji Li, Yuanhang Liao, Guan Gui, Jianwen Sheng

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guping ZhongDepartment of Gastroenterology, The People's Hospital of Yichun City, Jiangxi, China.
Xiaojin LuoDepartment of Urology, The People's Hospital of Yichun City, Jiangxi, China.
Ji LiDepartment of Gastroenterology, The People's Hospital of Yichun City, Jiangxi, China.
Yuanhang LiaoDepartment of Gastroenterology, The People's Hospital of Yichun City, Jiangxi, China.
Guan GuiDepartment of Gastroenterology, The People's Hospital of Yichun City, Jiangxi, China.
Jianwen ShengDepartment of Gastroenterology, The People's Hospital of Yichun City, Jiangxi, China.ORCID https://orcid.org/0000-0003-2308-9346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe methionine synthase reductase (

methodsWe performed a comprehensive and systematic search of PubMed, Google Scholar, MEDLINE, Science Direct, Scopus, CNKI, and Web of Science. Five studies were included in this meta-analysis to determine whether MTRR rs1532268 polymorphism contributes to the risk of GC.

resultsPooled data indicated that the MTRR rs1532268 polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 1.01-1.29) and dominant model (OR = 1.14, 95% CI = 1.00-1.30). In the analysis stratified by ethnicity, no relationship was found in Whites or Asians.

conclusionOur meta-analysis suggests a positive correlation between MTRR rs1532268 polymorphism and GC development.

Indexed as

Stomach NeoplasmsCase-Control StudiesFerredoxin-NADP ReductaseGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideRisk FactorsFerredoxin-NADP Reductasemethionine synthase reductasebiomarkergastric cancermeta-analysisMethionine synthase reductasepolymorphismsusceptibility

Identifiers

PMID35579185
PMCPMC9127855
OpenAlexW4280544208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.