Evidence map›Paper›PMID 35579181›Full record

ArticleThe Journal of international medical research2022

Associations between bone mineral density and chronic obstructive pulmonary disease.

Xiaodiao Zhang, Keke Ding, Xiaqi Miao, Jianing Wang, Binbin Hu, Jiamin Shen, Xueting Hu, Yage Xu, Beibei Yu, Tingting Tu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Xiaodiao ZhangDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-1197-3276
Keke DingDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiaqi MiaoDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jianing WangDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Binbin HuDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiamin ShenDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xueting HuDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yage XuDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Beibei YuDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tingting TuDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Aiju LinDepartment of Endocrinology, Bone Density Research Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xianjing ChenDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yiben HuangDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-4964-6158
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the relationship between chronic obstructive pulmonary disease (COPD) severity and bone mineral density (BMD) in the whole body and different body areas.

methodsThis retrospective, cross-sectional study included patients with COPD. Demographic and lung function data, COPD severity scales, BMD, and T scores were collected. Patients were grouped by high (≥-1) and low (<-1) T scores, and stratified by body mass index, airway obstruction, dyspnoea, and exercise capacity (BODE) index. The relationship between whole-body BMD and BODE was evaluated by Kendall's tau-b correlation coefficient. Risk factors associated with COPD severity were identified by univariate analyses. BMD as an independent predictor of severe COPD (BODE ≥5) was verified by multivariate logistic regression. BMD values in different body areas for predicting severe COPD were assessed by receiver operating characteristic curves.

resultsOf 88 patients with COPD, lung-function indicators and COPD severity were significantly different between those with high and low T scores. Whole-body BMD was inversely related to COPD severity scales, including BODE. Multivariate logistic regression revealed that BMD was independently associated with COPD severity. The area under the curve for pelvic BMD in predicting severe COPD was 0.728.

conclusionBMD may be a novel marker in predicting COPD severity, and pelvic BMD may have the strongest relative predictive power.

Indexed as

Bone DensityPulmonary Disease, Chronic ObstructiveBody Mass IndexCross-Sectional StudiesDyspneaHumansRetrospective StudiesSeverity of Illness IndexBODEbone mineral densityCOPDlung functionpelvic BMDT score

Identifiers

PMID35579181
PMCPMC9127852
OpenAlexW4280507763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.