ArticleInternational journal of epidemiology2023
Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
Article in International journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.
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The trial behind it
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Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- The role of nutritional vitamin D on microinflammation and nutritional status in maintenance hemodialysis patients: a meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies.Nutrition reviews · 2025Pooled it
- Pooled it
- Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review.The journal of nutrition, health & aging · 2023Pooled it
- Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis.PloS one · 2023Pooled it
- Low-grade inflammation from prenatal period to age 6-8 years in a Vitamin D trial.Pediatric research · 2024Trial
- Article
- Vitamin D as a cellular endocrine system: Tissue-specific microcircuits, immune reprogramming, and metabolic resistance.iScience · 2026Review
- Climate Change and Sarcopenia: Mechanisms, Vulnerabilities, and Public Health Implications.Calcified tissue international · 2026Review
- Suboptimal Vitamin D Status Is Associated withNutrients · 2026Article
- Vitamin D and vitamin D receptor polymorphisms modify cardiovascular outcomes in asthma: a prospective cohort study based on the UK Biobank.BMC pulmonary medicine · 2026Article
- Observational
- Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies.Frontiers in neuroscience · 2026Review
- Postprandial glycemic response in different ethnic groups in East London and its association with vitamin D status: Study protocol for an acute randomized crossover trial.Nutrition and health · 2025Article
- Exploring the Association of Vitamin D and VDR Polymorphisms with Disease Severity in COVID-19 and Influenza.Biomedicines · 2025Article
- Article
- Assessment of the Significance of LP-PLA2, DPYSL2, and 8-OHdG in the Oncological Diagnosis of Patients with Brain Tumors and Vitamin D Deficiency.International journal of molecular sciences · 2025Article
- Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study.Journal of cosmetic dermatology · 2025Article
- Gut Microbiota, Microbial Metabolites, and Inflammation in Cardiac Surgery: Implications for Clinical Outcomes-A Narrative Review.Microorganisms · 2025Review
- First metatarsophalangeal joint synovial hypertrophy associated with vitamin D status in type 2 diabetes mellitus: An ultrasound-graded study.World journal of diabetes · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundLow vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.
methodsMR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] and CRP concentrations were instrumented using 35 and 46 genome-wide significant variants, respectively.
resultsIn non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ∼50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations. Neither linear or non-linear MR analysis supported a causal effect of serum CRP level on 25(OH)D concentration (Plinear = 0.32 and Pnon-linear = 0.76).
conclusionThe observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency. Correction of low vitamin D status may reduce chronic inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.