Evidence map›Paper›PMID 35578992›Full record

ArticlemSphere2022

Comparative Genomics Identifies Features Associated with Methicillin-Resistant Staphylococcus aureus (MRSA) Transmission in Hospital Settings.

Timileyin Adedrian, Stephanie Hitchcock, Lyndsay M O'Hara, Jane M Michalski, J Kristie Johnson, David P Calfee, Loren G Miller, Tracy H Hazen, Anthony D Harris, David A Rasko

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Timileyin AdedrianDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Stephanie HitchcockDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Lyndsay M O'HaraDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jane M MichalskiInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Kristie JohnsonDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
David P CalfeeDivision of Infectious Diseases, Weill Cornell Medicine, New York, USA.
Loren G MillerLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Tracy H HazenInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Anthony D HarrisDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
David A RaskoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7337-7154
University of Maryland, Baltimore · USCornell University · USUCLA Medical Center · US

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RASKO, DAVID A · 2014 to 2023
$36.5M
Epidemiology of CRE and MRSA transmission: patient and organism factorsR01AI121146 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRIS, ANTHONY D · 2016 to 2019
$2.5M
NIAID NIH HHS R01 AI121146NIAID NIH HHS U19 AI110820
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious public health concern in the United States. Patients colonized and/or infected can transmit MRSA to healthcare workers and subsequent patients However, the components of this transmission chain are just becoming evident, including certain patient factors, specific patient-healthcare worker interactions, and microbial factors. We conducted a comparative genomic analysis of 388 isolates from four hospitals in three states: Maryland, California, and New York. Isolates from nasal surveillance or clinical cultures were categorized as high, moderate, or low transmission surrogate outcomes based on the number of times the species was identified on the gloves or gowns of healthcare providers. The comparative analyses included a single gene, multigene, and core genome phylogenetic analysis, as well as a genome-wide association analysis to identify molecular signatures associated with the observed transmission surrogate outcomes, geographic origin, or sample source of isolation. Based on the phylogenetic analysis, 95% (

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsGenome-Wide Association StudyGenomicsHospitalsHumansPhylogenyStaphylococcus aureusUnited Statescomparative studiesMRSAStaphylococcus aureustransmission

Identifiers

PMID35578992
PMCPMC9241550
OpenAlexW4280518915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.