Evidence map›Paper›PMID 35578987›Full record

ArticleThe Journal of infectious diseases2022

Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda.

John Rek, Sara Lynn Blanken, Joseph Okoth, Daniel Ayo, Ismail Onyige, Eric Musasizi, Jordache Ramjith, Chiara Andolina, Kjerstin Lanke, Emmanuel Arinaitwe and 8 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Magnitude and durability of ProC6C-AlOH/Matrix-MHuman vaccines & immunotherapeutics · 2025
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  8. Review
  9. Article
  10. Article
  11. Article
  12. High-AltitudeOpen forum infectious diseases · 2026
    Article
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  14. Article
  15. Article
  16. Article
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  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

John RekInfectious Diseases Research Collaboration, Kampala, Uganda.
Sara Lynn BlankenDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Joseph OkothInfectious Diseases Research Collaboration, Kampala, Uganda.
Daniel AyoInfectious Diseases Research Collaboration, Kampala, Uganda.
Ismail OnyigeInfectious Diseases Research Collaboration, Kampala, Uganda.
Eric MusasiziInfectious Diseases Research Collaboration, Kampala, Uganda.
Jordache RamjithDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
Chiara AndolinaDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Kjerstin LankeDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Emmanuel ArinaitweInfectious Diseases Research Collaboration, Kampala, Uganda.
Peter OlwochInfectious Diseases Research Collaboration, Kampala, Uganda.
Katharine A CollinsDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Moses R KamyaDepartment of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Grant DorseyDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, USA.
Chris DrakeleyDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Sarah G StaedkeDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Teun BousemaDepartment of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0003-2666-094X
Melissa D ConradDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, USA.

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2010 to 2026
$29.3M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
University of California Global Health Institute Program for Fellows and ScholarsR25TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COHEN, CRAIG R, STRATHDEE, STEFFANIE A. · 2012 to 2017
$6.4M
The impact of antimalarials and insecticide resistance on malaria transmission in UgandaK01TW010868 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONRAD, MELISSA D · 2018 to 2022
$706k
Resistance of Malaria Parasites to Artemisinin-Based Combination TherapiesR56AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2008 to 2008
$618k
FIC NIH HHS D43 TW009343FIC NIH HHS K01 TW010868FIC NIH HHS P0529898FIC NIH HHS R25 TW009343NIAID NIH HHS R01 AI075045NIAID NIH HHS R56 AI075045NIAID NIH HHS U19 AI089674NIH HHS AI089674
6 · The paper itself

Abstract

Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito feeding assays. In asymptomatic infections, gametocyte densities were positively associated with the proportion of infected mosquitoes (β = 1.60; 95% CI, 1.32-1.92; P < .0001). Combining transmissibility and abundance in the population, symptomatic and asymptomatic infections were estimated to contribute to 5.3% and 94.7% of the infectious reservoir, respectively. School-aged children (5-15 years old) contributed to 50.4% of transmission events and were important drivers of malaria transmission.

Indexed as

AnophelesBurkitt LymphomaMalariaMalaria, FalciparumAdolescentAnimalsAsymptomatic InfectionsChildChild, PreschoolHumansPlasmodium falciparumUgandagametocytesmalaria transmissionmosquito feeding assaysPlasmodium falciparumUganda

Identifiers

PMID35578987
PMCPMC9441202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.