ArticleeLife2022
Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Multi-tissue transcriptomic profiling reveals the internal physiological landscape of laying hens in cage and cage-free systems.Poultry science · 2026Article
- Maintaining microbiota across diverse symbiotic organs inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Chronic cold stress induced transcriptomic alterations in multi-metabolically active tissues of pigs.Communications biology · 2025Article
- Developmental low-dose bisphenol A exposure leads to extensive transcriptome female masculinization and male feminization later in life.Communications medicine · 2025Article
- Effects of FGF21, soluble TGFBR2, and environmental temperature on metabolic dysfunction in lipodystrophic mice.JCI insight · 2025Article
- Review
- Cold exposure stimulates cross-tissue metabolic rewiring to fuel glucose-dependent thermogenesis in brown adipose tissue.Science advances · 2025Article
- Enhanced propionate and butyrate metabolism in cecal microbiota contributes to cold-stress adaptation in sheep.Microbiome · 2025Article
- Full-length transcriptome sequencing of pepper fruit during development and construction of a transcript variation database.Horticulture research · 2024Article
- Brown adipose tissue but not tibia exhibits a dramatic response to acute reduction in environmental temperature in growing male mice.Bone reports · 2023Article
- Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis.Redox biology · 2023Article
- Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body.PLoS genetics · 2023Article
- The Influence of Ambient Temperature on Adipose Tissue Homeostasis, Metabolic Diseases and Cancers.Cells · 2023Review
- Assessment of cold exposure-induced metabolic changes in mice using untargeted metabolomics.Frontiers in molecular biosciences · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermal adaptation is an extensively used intervention for enhancing or suppressing thermogenic and mitochondrial activity in adipose tissues. As such, it has been suggested as a potential lifestyle intervention for body weight maintenance. While the metabolic consequences of thermal acclimation are not limited to the adipose tissues, the impact on the rest of the tissues in context of their gene expression profile remains unclear. Here, we provide a systematic characterization of the effects in a comparative multi-tissue RNA sequencing approach following exposure of mice to 10 °C, 22 °C, or 34 °C in a panel of organs consisting of spleen, bone marrow, spinal cord, brain, hypothalamus, ileum, liver, quadriceps, subcutaneous-, visceral- and brown adipose tissues. We highlight that transcriptional responses to temperature alterations exhibit a high degree of tissue-specificity both at the gene level and at GO enrichment gene sets, and show that the tissue-specificity is not directed by the distinct basic gene expression pattern exhibited by the various organs. Our study places the adaptation of individual tissues to different temperatures in a whole-organism framework and provides integrative transcriptional analysis necessary for understanding the temperature-mediated biological programming.
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