ArticleCardiology journal2022
Optimal surgical timing after post-infarction ventricular septal rupture.
Article in Cardiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 31 citations in OpenAlex.
- Temporary Mechanical Circulatory Support in Patients in Cardiogenic Shock Requiring Cardiac Surgery: Protected Cardiac Surgery Concept.Journal of clinical medicine · 2026Review
- Optimal timing of surgery and analysis of prognostic factors for myocardial infarction complicated by ventricular septal rupture.Cardiovascular diagnosis and therapy · 2026Article
- Acute myocardial infarction with ventricular septal rupture: Clinical characteristics, prognosis factors, and treatment strategies.World journal of cardiology · 2025Review
- The Hannover Postinfarction Ventricular Septal Rupture Score: A New Scoring System Predicting 30-Day Mortality.CJC open · 2025Article
- Concurrent left ventricular pseudoaneurysm and ventricular septal rupture complicating an inferior myocardial infarction: A case report.Radiology case reports · 2025Article
- Interventricular septal dissection secondary to acute inferior myocardial infarction: case series and literature review.Journal of cardiothoracic surgery · 2025Review
- Article
- Ventricular apical wall rupture and ventricular aneurysm formation concurrent with ventricular septal dissection and rupture due to ST-segment elevation myocardial infarction: a case report.BMC cardiovascular disorders · 2024Article
- Repair of posterior ventricular septal rupture by right atrial approach.Journal of geriatric cardiology : JGC · 2023Article
- Mechanical complications of acute myocardial infarction: a not "mechanical" preventive and therapeutic strategy.Journal of thoracic disease · 2022Article
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Authors and funding
17 authors at 14 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundVentricular septal rupture (VSR) following acute myocardial infarction (AMI) is a dangerous condition. Surgical VSR closure is the definitive therapy, but there is controversy regarding the surgical timing and the bridging therapy between diagnosis and intervention. The objective of this study is to analyze the ideal time of surgical repair and to establish the contribution of mechanical circulatory support (MCS) devices on the prognosis.
methodsWe designed an observational, retrospective, multicenter study, selecting all consecutive patients with post-AMI VSR between January 1, 2008 and December 31, 2018, with non-exclusion criteria. The main objective of this study was to analyze the optimal timing for surgical repair of post-AMI VSR. Secondary endpoints were to determine which factors could influence mortality in the patients of the surgical group.
resultsA total of 141 patients were included. We identified lower mortality rates with an odds ratio of 0.3 (0.1-0.9) in patients operated on from day 4 compared with the surgical mortality in the first 24 hours after VSR diagnosis. The use of MCS was more frequent in patients treated with surgery, particularly for intra-aortic balloon pump (IABP; 79.6% vs. 37.8%, p < 0.001), but also for veno-arterial extracorporeal membrane oxygenation (VA-ECMO; 18.2% vs. 6.4%, p = 0.134). Total mortality was 91.5% for conservative management and 52.3% with surgical repair (p < 0.001).
conclusionsIn our study, we observed that the lowest mortality rates in patients with surgical repair of post-AMI VSR were observed in patients operated on from day 4 after diagnosis of VSR, compared to earlier interventions.
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