Evidence map›Paper›PMID 35578755›Full record

ArticleCardiology journal2022

Agreement between Murray law-based quantitative flow ratio (μQFR) and three-dimensional quantitative flow ratio (3D-QFR) in non-selected angiographic stenosis: A multicenter study.

Carlos Cortés, Lili Liu, Scarlet Luisa Berdin, Pablo M Fernández-Corredoira, Ruiyan Zhang, Ulrich Schäfer, María López, José A Diarte, Shengxian Tu, Juan Luis Gutiérrez-Chico

Abstract readMulticenter Study
In one paragraph

Article in Cardiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic review and meta-analysis of Murray's law in the coronary arterial circulation.American journal of physiology. Heart and circulatory physiology · 2024
    Pooled it
  2. VERMONT μQFR: Diagnostic Accuracy of Murray Law-Based 2D-μQFR Compared to 3D-μQFR and vFFR.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
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  11. Functional or anatomical assessment of non-culprit lesions in acute myocardial infarction.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
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  20. Functional coronary angiography for the assessment of the epicardial vessels and the microcirculation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlos CortésMiguel Servet University Hospital, Zaragoza, Spain.ORCID 0000-0002-9332-4236
Lili LiuDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Scarlet Luisa BerdinBundeswehrkrankenhaus (Federal Army Military Hospital), Hamburg, Germany.
Pablo M Fernández-CorredoiraMiguel Servet University Hospital, Zaragoza, Spain.
Ruiyan ZhangDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ulrich SchäferBundeswehrzentralkrankenhaus (Federal Army Central Military Hospital), Koblenz, Germany.
María LópezNursing High School, University of Valladolid, Valladolid, Spain.
José A DiarteMiguel Servet University Hospital, Zaragoza, Spain.
Shengxian TuMed-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Juan Luis Gutiérrez-ChicoDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. juanluis.gutierrezchico@ictra.es.ORCID 0000-0002-0812-7925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe agreement between single-projection Murray-based quantitative flow ratio (mQFR) and conventional three-dimensional quantitative flow ratio (3D-QFR) has not been reported hitherto.

methodsPatients from a multinational database were randomly selected for the study of agreement, according to sample size calculation. Both conventional 3D-QFR and mQFR were analyzed for all available arteries at a central corelab by independent analysts, blinded to each other's results.

resultsNinety-eight coronary arteries from 35 patients were finally analyzed. Median 3D-QFR was 0.82 (interquartile range 0.78-0.87). The intraclass correlation coefficient for the absolute agreement between 3D-QFR and mQFR was 0.996 (95% confidence interval [CI]: 0.993-0.997); Lin's coefficient 0.996 (95% CI: 0.993-0.997), without constant or proportional bias (intercept = 0 and slope = 1 in orthogonal regression). As dichotomous variable, there was absolute agreement between mQFR and 3D-QFR, resulting in no single false positive or negative. Kappa index was 1 and the diagnostic accuracy 100%.

conclusionsmQFR using a single angiographic projection showed almost perfect agreement with standard 3D-QFR. These results encourage the interchangeable use of mQFR and 3D-QFR, which can be interesting to improve QFR feasibility in retrospective studies, wherein appropriate double angiographic projections might be challenging to obtain.

Indexed as

Coronary Artery DiseaseCoronary StenosisFractional Flow Reserve, MyocardialConstriction, PathologicCoronary AngiographyCoronary VesselsHumansPredictive Value of TestsRetrospective StudiesSeverity of Illness Indexcomputational physiologycoronary heart diseasecoronary physiologyMurray lawquantitative flow ratioresting indexμQFR

Identifiers

PMID35578755
PMCPMC9170317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.