ArticleFrontiers in nutrition2022
Folic Acid Levels During Pregnancy Regulate Trophoblast Invasive Behavior and the Possible Development of Preeclampsia.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The one-carbon metabolism as an underlying pathway for placental DNA methylation - a systematic review.Epigenetics · 2024Pooled it
- Article
- High folic acid supplementation is associated with vaginal bleeding in early pregnancy in a fetal sex-specific manner: findings from two prospective cohort studies.Reproductive health · 2026Article
- Epigenetic mechanisms in preeclampsia: translational therapeutic strategies and precision-medicine perspectives.Journal of medicine and life · 2026Review
- Excess folic acid disrupts placental endocrine functionFrontiers in nutrition · 2026Article
- The roles of folate, MTHFR genetics, vitamin B12 in pregnancy outcomes.Frontiers in nutrition · 2026Review
- First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort.Human reproduction (Oxford, England) · 2025Observational
- The relationship between folic acid deficiency and preeclampsia-like phenotypes in rats.BMC pregnancy and childbirth · 2025Article
- Prenatal alcohol exposure is associated with altered feto-placental blood flow and sex-specific placental changes.JCI insight · 2025Article
- Placenta-Related Parameters at Delivery in Relation to Folic Acid Supplementation in Different Pregnancies.Nutrients · 2024Article
- Article
- Impact of prematurity on LINE-1 promoter methylation.Epigenomics · 2024Article
- Advances in Folic Acid Biosensors and Their Significance in Maternal, Perinatal, and Paediatric Preventive Medicine.Biosensors · 2023Review
- Maternal metabolism influences neural tube closure.Trends in endocrinology and metabolism: TEM · 2023Review
- Article
- The role of maternal choline, folate and one-carbon metabolism in mediating the impact of prenatal alcohol exposure on placental and fetal development.The Journal of physiology · 2023Review
- Biological Role of Folic Acid in Pregnancy and Possible Therapeutic Application for the Prevention of Preeclampsia.Biomedicines · 2023Review
- Palmitic Acid Impedes Extravillous Trophoblast Activity by Increasing MRP1 Expression and Function.Biomolecules · 2022Article
- Circular RNA hsa-circ-0005238 enhances trophoblast migration, invasion and suppresses apoptosisFrontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: One of the unique features of placentation is its similarity to tumorigenesis yet being very well regulated. It allows rapid proliferation, migration, and invasion of mononuclear trophoblast cells into the maternal uterus and remodeling the maternal vasculature. This pseudomalignant nature of trophoblastic cells is strictly regulated and its importance becomes evident in abnormal pregnancies that are characterized by aberrant trophoblast proliferation/invasion like preeclampsia. In addition to this, the importance of folic acid supplementation during pregnancy is well documented. We aimed to analyze the molecular and epigenetic regulation of the pseudomalignant nature of placentation Methods: Placental tissue samples were collected from different pregnancies in three different gestational stages. We estimated the impact of folic acid levels on global methylation, Results: Development of preeclampsia was observed to be associated with lower folate levels in placental tissue, higher global methylation level, and higher expression of Conclusion: Lower folic acid levels are associated with preeclampsia development and folic acid supplementation regulates the invasive potential of placental trophoblasts as mediated by various epigenetic changes in the placenta suggesting the protective effect of folic acid against preeclampsia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.