Evidence map›Paper›PMID 35578398›Full record

Trial reportAIDS care2023

Two or more significant life-events in 6-months are associated with lower rates of HIV treatment and virologic suppression among youth with HIV in Uganda and Kenya.

Florence Mwangwa, Edwin D Charlebois, James Ayieko, Winter Olio, Douglas Black, James Peng, Dalsone Kwarisiima, Jane Kabami, Laura B Balzer, Maya L Petersen and 4 more

Abstract readClinical Trial
In one paragraph

Trial report in AIDS care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Florence MwangwaInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0001-9467-0950
Edwin D CharleboisDepartments of Medicine and Pediatrics, University of California, San Francisco, CA, USA.ORCID 0000-0001-7237-2119
James AyiekoKenya Medical Research Institute (KEMRI), Nairobi, Kenya.ORCID 0000-0002-0324-4006
Winter OlioKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Douglas BlackDepartments of Medicine and Pediatrics, University of California, San Francisco, CA, USA.
James PengDepartments of Medicine and Pediatrics, University of California, San Francisco, CA, USA.ORCID 0000-0002-8245-8319
Dalsone KwarisiimaInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0003-2886-9261
Jane KabamiInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0002-0265-3174
Laura B BalzerDepartment of Biostatistics & Epidemiology, University of Massachusetts, Amherst, MA, USA.ORCID 0000-0002-3730-410X
Maya L PetersenBerkeley School of Public Health, University of California, Berkeley, CA, USA.ORCID 0000-0002-5505-153X
Bill KapogiannisMaternal and Pediatric Infectious Diseases Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0754-9090
Moses R KamyaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0001-9106-4234
Diane V HavlirDepartments of Medicine and Pediatrics, University of California, San Francisco, CA, USA.ORCID 0000-0003-0761-3136
Theodore D RuelDepartments of Medicine and Pediatrics, University of California, San Francisco, CA, USA.ORCID 0000-0002-1105-9126

Funding

Strategic antiretroviral therapy and HIV testing for youth in rural AfricaUH3HD096915 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2020 to 2022
$5.7M
Strategic antiretroviral therapy and HIV testing for youth in rural Africa (SATURN)UG3HD096915 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2018 to 2019
$3.4M
NICHD NIH HHS UG3 HD096915NICHD NIH HHS UH3 HD096915
6 · The paper itself

Abstract

Youth living with HIV in sub-Saharan Africa have poor HIV care outcomes. We determined the association of recent significant life-events with HIV antiretroviral treatment (ART) initiation and HIV viral suppression in youth aged 15-24 years living with HIV in rural Kenya and Uganda. This was a cross-sectional analysis of 995 youth enrolled in the SEARCH Youth study. At baseline, providers assessed recent (within 6 months) life-events, defined as changes in schooling/employment, residence, partnerships, sickness, incarceration status, family strife or death, and birth/pregnancy, self-reported alcohol use, being a parent, and HIV-status disclosure. We examined the frequencies of events and their association with ART status and HIV viral suppression (<400 copies/ul). Recent significant life-events were prevalent (57.7%). Having

Indexed as

Anti-HIV AgentsHIV InfectionsAdolescentAnti-Retroviral AgentsCross-Sectional StudiesFemaleHumansKenyaPregnancyUgandaViral LoadAnti-HIV AgentsAnti-Retroviral AgentsAfricaHIVtreatmentYouth

Identifiers

PMID35578398
PMCPMC9666617

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.