ReviewJournal of physiological anthropology2022
Development of the circadian system in early life: maternal and environmental factors.
Review in Journal of physiological anthropology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of combined versus single circadian interventions in neonatal and pediatric intensive care units: a systematic review with meta-analysis.Frontiers in neurologyPooled it
- Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study.PloS one · 2022Trial
- Article
- Stage-Specific Effects of Maternal Circadian Rhythm Disruption during Pre-Pregnancy, Pregnancy, and Lactation on Behavioral and Neurobiological Outcomes in Male Rat Offspring.Molecular neurobiology · 2026Article
- Social Jetlag Emerges in Preadolescent Children Despite Adequate Sleep Duration: Evidence for Child-Mother Circadian Misalignment Associations.Journal of sleep research · 2026Article
- Feeding Mode Is Associated with Infant Night Sleep Trajectories During the First Postnatal Year.Nutrients · 2026Article
- Circadian Rhythm Disorder-Related Dysfunctions are Exacerbated by Aging and Ameliorated by Time-Restricted Feeding.Neuroscience bulletin · 2026Article
- Comparison of sensory processing skills in 7-12 month old colic and non-colic infants.BMC pediatrics · 2026Article
- The Circadian Composition of Breast Milk: A Natural Starting Point for Chrononutrition.Current nutrition reports · 2026Review
- Circadian rhythms of arousal in parent-child interaction: a 24-hour co-regulation process.Child development perspectives · 2026Article
- PMToxics · 2026Article
- Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity.Nutrients · 2026Review
- Establishment of Circadian Rhythm Experiments using Bengalese Finches.The journal of poultry science · 2026Article
- Growth factors, body composition and energy expenditure in late preterm and term infants during the first 4 months of life: a prospective cohort study.Molecular and cellular pediatrics · 2025Article
- Article
- Altered sleep and inflammation are related to outcomes in neonatal encephalopathy.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Sleep profile in patients with septo-optic-pituitary dysplasia: protocol for a prospective cohort study.BMJ open · 2025Article
- The relationship between physical activity, sleep, and negative emotions in physically weak college students.Frontiers in public health · 2025Article
- Embryonic Circadian Rhythm Establishment, Homeostasis, and Dysfunction During Organogenesis.Stem cells international · 2025Review
- Sleep Across the Lifespan: A Neurobehavioral Perspective.Current sleep medicine reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, an adaptable internal biological system generates circadian rhythms that maintain synchronicity of behavior and physiology with the changing demands of the 24-h environment. Development of the circadian system begins in utero and continues throughout the first few years of life. Maturation of the clock can be measured through sleep/wake patterns and hormone secretion. Circadian rhythms, by definition, can persist in the absence of environmental input; however, their ability to adjust to external time cues is vital for adaptation and entrainment to the environment. The significance of these external factors that influence the emergence of a stable circadian clock in the first years of life remain poorly understood. Infants raised in our post-modern world face adverse external circadian signals, such as artificial light and mistimed hormonal cues via breast milk, which may increase interference with the physiological mechanisms that promote circadian synchronization. This review describes the very early developmental stages of the clock and common circadian misalignment scenarios that make the developing circadian system more susceptible to conflicting time cues and temporal disorder between the maternal, fetal, infant, and peripheral clocks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.