ArticleBMC palliative care2022
A prospective cohort study assessing aggressive interventions at the end-of-life among patients with solid metastatic cancer.
Article in BMC palliative care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02850640 (Cost and Medical Care of Patients With Advanced Serious Illness in Singapore), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cost and Medical Care of Patients With Advanced Serious Illness in Singapore (COMPASS) Study
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Palliative prognostic scores for survival prediction of cancer patients: a systematic review and meta-analysis.Journal of the National Cancer Institute · 2024Pooled it
- Palliative care use and end-of-life care quality in HR+/HER2- metastatic breast cancer.Breast cancer research and treatment · 2025Article
- Breaking with the status quo in end-of-life care through de-implementation.Journal of internal medicine · 2025Review
- Reverse Time-to-Death as Time-Scale in Time-to-Event Analysis for Studies of Advanced Illness and Palliative Care.Statistics in medicine · 2025Article
- More competent informal caregivers reduce advanced cancer patients' unplanned healthcare use and costs.Cancer medicine · 2024Article
- Goals of Care Among Patients With Advanced Cancer and Their Family Caregivers in the Last Years of Life.JAMA network open · 2024Article
- Multifactorial risk factors for hospital readmissions among patients with symptoms of advanced heart failure.ESC heart failure · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany patients with a solid metastatic cancer are treated aggressively during their last month of life. Using data from a large prospective cohort study of patients with an advanced cancer, we aimed to assess the number and predictors of aggressive interventions during last month of life among patients with solid metastatic cancer and its association with bereaved caregivers' outcomes.
methodsWe used data of 345 deceased patients from a prospective cohort study of 600 patients. We surveyed patients every 3 months until death for their physical, psychological and functional health, end-of-life care preference and palliative care use. We surveyed their bereaved caregivers 8 weeks after patients' death regarding their preparedness about patient's death, regret about patient's end-of-life care and mood over the last week. Patient data was merged with medical records to assess aggressive interventions received including hospital death and use of anti-cancer treatment, more than 14 days in hospital, more than one hospital admission, more than one emergency room visit and at least one intensive care unit admission, all within the last month of life.
results69% of patients received at least one aggressive intervention during last month of life. Patients hospitalized during the last 2-12 months of life, male patients, Buddhist or Taoist, and with breast or respiratory cancer received more aggressive interventions in last month of life. Patients with worse functional health prior to their last month of life received fewer aggressive interventions in last month of life. Bereaved caregivers of patients receiving more aggressive interventions reported feeling less prepared for patients' death.
conclusionFindings suggest that intervening early in the sub-group of patients with history of hospitalization prior to their last month may reduce number of aggressive interventions during last month of life and ultimately positively influence caregivers' preparedness for death during the bereavement phase.
trial registrationNCT02850640 .
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