Evidence map›Paper›PMID 35578115›Full record

ArticleClinical oral investigations2022

B cell depletion in patients with rheumatoid arthritis is associated with reduced IL-1β in GCF.

Mükerrem Hatipoğlu, Özlem Daltaban, Sevcan Uğur, Kemal Üstün, Cahit Kaçar, Tiraje Tuncer, Alpdogan Kantarci

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Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mükerrem HatipoğluDepartment of Periodontology, Faculty of Dentistry, Akdeniz University, Antalya, Turkey.
Özlem DaltabanDepartment of Periodontology, Faculty of Dentistry, Akdeniz University, Antalya, Turkey.
Sevcan UğurDepartment of Rheumatology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Kemal ÜstünDepartment of Periodontology, Faculty of Dentistry, Akdeniz University, Antalya, Turkey. Kemalustun@hotmail.com.ORCID http://orcid.org/0000-0001-9696-2041
Cahit KaçarDepartment of Physical Therapy and Rehabilitation, Rheumatology Division, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Tiraje TuncerDepartment of Physical Therapy and Rehabilitation, Rheumatology Division, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Alpdogan KantarciDepartment of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA, USA.
Akdeniz University · TRAlanya University · TR

Funding

Akdeniz Üniversitesi TSA-2017-2431
6 · The paper itself

Abstract

objectivesWe evaluated the effect of B cell depletion on the clinical periodontal findings and IL-1β and MMP-8 levels of the gingival crevicular (GCF) fluid in patients with rheumatoid arthritis (RA). MATERIALS AND

methodsSeventy patients were included in this case-control study. Twenty patients with RA were undergoing B-cell depletion treatment. The second group of RA patients (n = 20) were undergoing non-B-cell depletion treatment with Disease-Modifying Anti-Rheumatic Drugs (DMARD). Control group, with no RA, consisted of 30 individuals. Periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI), and plaque index (PI) were recorded. IL-1β and MMP-8 levels in GCF were determined using enzyme-linked immunosorbent assay. Rheumatological parameters including Disease Activity Score-28 (DAS-28), rheumatoid factor levels (RF), and anti-cyclic citrullinated peptide levels were included in the data analyses.

resultsAll groups were similar in PD, CAL, BOP, GI, and PI measures. GCF IL-1β levels were 1.85 ± 1.67 pg in the B-cell depletion group, 10.50 ± 13.16 pg in the DMARD group, and 34.12 ± 29.45 pg in the control group (p < 0.001). MMP-8 levels were 21.00 ± 4.23 pg in the B-cell depletion group, 8.16 ± 6.94 pg in the DMARD group, and 21.45 ± 8.67 pg in the control group (p < 0.001). DAS 28, RF, and anti-CCP were similar in RA groups.

conclusionsGCF IL-1β levels were significantly lower in B cell depletion group, and MMP-8 levels were significantly lower in DMARD group, suggesting that rheumatoid arthritis treatments may modify biochemical parameters of GCF. CLINICAL RELEVANCE: This study suggests that host modulation therapies in RA can reduce local production of IL-1β and MMP-8. Reduction of these inflammatory cytokines and enzymes may have a beneficial effect in controlling periodontal tissue destruction.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidCase-Control StudiesGingival Crevicular FluidHumansInterleukin-1betaMatrix Metalloproteinase 8Repressor ProteinsAntirheumatic AgentsGCFC2 protein, humanIL1B protein, humanInterleukin-1betaMatrix Metalloproteinase 8Repressor ProteinsBiological therapyGingival crevicular fluidPeriodontitisRheumatoid arthritis

Identifiers

PMID35578115
OpenAlexW4280506035

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.